银屑病遗传流行病学初步分析  

Preliminary analysis of genetic epidemiology of psoriasis

作　　者：刘涛峰[1,2,3] 张学军[1,2,3] 杨森 黄世兰[1,2,3] 骆娣凤[1,2,3] 王彦青 肖尚喜[1,2,3] 刘兢 赵国屏[1,2,3] 

机构地区：[1]安徽医科大学第一附属医院皮肤科 [2]中国科学技术大学生命科学学院 [3]中国科学院上海生物工程中心

出　　处：《安徽医科大学学报》1998年第5期354-356,共3页Acta Universitatis Medicinalis Anhui

基　　金：中国科学院人类基因组计划子课题

摘　　要：目的探讨遗传因素在银屑病发病中所起的作用。方法采用调查表形式对２４７例银屑病患者进行调查，用Ｅｐｉｉｎｆｏ６．０软件及Ｆａｌｃｏｎｅｒ法对数据资料进行统计计算。结果２４７例银屑病患者中，有阳性家族史的６３例（２５．５１％），其中一级亲属的患病率为４．２１％，二组亲属的患病率为０．７１％；先证者一级亲属的遗传度为０．７８２±０．０３４，二级亲属的遗传度为０．６９８±０．０８８；Ⅰ型银屑病患者中，一级亲属的遗传度为０．７９７±０．０３６，二级亲属的遗传度为０．７５２±０．０９２，Ⅱ型银屑病患者中，一级亲属的遗传度为０．７３０±０．０８９，二级亲属的遗传度为０．１７１±０．３８０。结论银屑病是一种多基因遗传病，遗传因素在其发病中起重要作用。Objective To investigate the effects of genetic factor on the onset of psoriasis. Methods 247 patients with psoriasis were studied by questionnaire. Epi info 6 0 and Falconer methods were applied for the statistic analysis. Results In 247 patients with psoriasis, there are 63 patients with positive family history (25 5%). The morbidity rate of the first and the second grade relatives are 4 21% and 0 71% respectively. The heritability of the first and second grade relatives are 0 782±0 034 and 0 698±0 088 respectively. In type Ⅰ psoriasis, the heritability of the first and the second grade relatives are 0.797±0.036 and 0 752±0 092 respectively. In type Ⅱ psoriasis, The heritability of the first and the second grade relatives are 0 730±0 089 and 0 171±0 380 respectively. Conclusion Psoriasis is a polygenic inheritable disease, the genetic factor plays an important role in its onset, and it is easier to inherit the disease in type Ⅰ psoriasis and the first grade relatives.

关 键 词：银屑病 遗传学 流行病学 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]