蒽环类药物对肿瘤患者心脏Tei指数影响的临床研究  

A clinical research on Tei index in assessment of Myocardial Toxicity in cancer patients treated with anthracyclines

作　　者：林剑英[1] 李涛[1] 陈茹[1] 李活霞[1] 

机构地区：[1]广州医学院附属肿瘤医院功能科,广东广州510095

出　　处：《实用临床医药杂志》2009年第10期30-32,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨利用心肌做功指数（MPI，Tei指数）早期检测和评估蒽环类药物（ATC）对肿瘤患者心脏毒性的临床价值。方法用多普勒法测定46例恶性肿瘤患者ATC化疗前和化疗后3～6个月左心Tei指数，常规超声心动图EF、FS和E／A指标。结果与化疗前比较，Tei指数相关参数中ATC化疗后左心室等容舒张时间（IRT）延长，等容舒张指数（IRT／ET）增大，E／A指标降低（P〈0．05）。左心室等容收缩时间（ICT），等容收缩指数（ICT／ET），EF和FS指标较化疗前无显著性差异。结论在早期评价ATC对肿瘤患者心脏功能损害方面，Tei指数、等容舒张指数是敏感的指标，E／A指标虽然在应用上有局限性，但也有一定参考意义。Objective To explore the clinical value of applying Tei index to assessing early cardiac function damage in cancer patients receiving cardiotoxic anthracycline chemotherapy. Methods Forty-six cancer patients treated with anthracycline chemotherapy were examined by echocardiography and Tei index, EF, FS and E/A were obtained by Doppler Method before chemotherapy and three--six months after chemotherapy. Results Parameters of Tel index showed that after chemotherapy, Left ventricular isovolumic relaxation time （IRT） was significantly prolonged, isovolumic relaxation index（IRT/ET） increased and E/A decreased（P〈0.05）. Left ventricular isovolumic contraction time （ICT）, isovolumic contraction index （ICT/ET）, EF and FS value had not significant difference. Conclusion Tei index and IRT/ET are two sensitive indicators in the early assessment of damage to the cardiac function of tumor patients caused by ATC, and E/A value has limitations in its application, but it still has certain reference value.

关 键 词：TEL指数 蒽环类药物 心脏功能 超声心动图 

分 类 号：R730.53[医药卫生—肿瘤]