美沙酮维持治疗对海洛因依赖患者心理健康状况的影响  

Effects of methadone maintenance therapy on psychological health status of patients with heroin dependence

作　　者：周春英[1] 朱宏志[1] 

机构地区：[1]南通市第四人民医院,江苏·南通226005

出　　处：《临床心身疾病杂志》2009年第6期532-533,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨美沙酮维持治疗对海洛因依赖患者心理健康状况的影响。方法将41例海洛因依赖患者设为研究组，给予美沙酮维持治疗1a，抽取社区35名一般资料与研究组相匹配的居民设为对照组。研究组入组时及治疗1a末采用症状自评量表评定心理健康状况，对照组于入组时进行评定。结果研究组经美沙酮维持治疗1a末，症状自评量表各因子分及阳性项目数均较入组时有显著下降，其中强迫症状、人际关系、焦虑、敌对、恐怖、精神病性因子分和阳性项目数均有显著或极显著性差异（P〈0．05或0．01）；入组时及治疗1a末症状自评量表各因子分及阳性项目数均显著高于对照组（P〈0．05或0．01）。结论海洛因依赖者存在诸多方面的心理健康问题，美沙酮维持治疗能使部分心理问题得以改善。Objective To explore the effects of methadone maintenance therapy on psychological health status of patients with heroin dependence. Methods 41 patients with heroin dependence were assigned to research group receiving methadone maintenance therapy for one year, 35 community matched residents of the same district to control group. Mental health staus was assesed with the Symptom Checklist-90（SCL- 90） at intake and at the end of one year maintenance therapy in the research and at intake in the control group. Results After 1-year methadone maintenance therapy,the scores of all factors and the number of positive items of SCL-90 lowered significantly compared with pretreatment in the research, of them scores of obsessive-compulsive symptom, interpersonal relation, anxiety, hostility, phobias, psychotie and the number of positive items had significant or very significant differences（P〈0.05 or 0.01） ; scores of all factors and the number of positive items were significantly higher in the research than in the control group at intake and after 1-year treatment （P〈0.05 or 0.01）. Conclution Patients with heroin dependence have many mental heath problems, methadone maintenance therapy can improve some of them.

关 键 词：海洛因依赖 美沙酮 维持治疗 心理健康 症状自评量表 

分 类 号：R737.9[医药卫生—肿瘤]