血管源性轻度认知障碍认知损害特点分析  

Analysis on Damage Features of Vascular Mild Cognitive Impairment

作　　者：高芳[1] 张允岭[1] 韩振蕴[1] 侯小兵[1] 金香兰[1] 陈宝鑫[1] 何婷婷[1] 

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《世界中西医结合杂志》2009年第11期793-796,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：首都医学发展科研基金联合攻关项目(No.SF-2005-3);2008年中医药行业科研专项(No.200807011);211工程重点学科建设项目;北京市新医药学科群建设项目(No.xk100270569)

摘　　要：目的分析血管源性轻度认知障碍的认知损害特点。方法参照国际公认的2006年NINDS-CSN关于血管源性认知障碍统一标准的建议制定诊断标准,进行敏感的神经心理学量表检测,由神经科专业医师筛查血管源性轻度认知障碍患者(VMCI组)及有血管源性危险因素但认知功能正常者作为对照组,进行认知功能的比较分析。结果两组MoCA视空间与执行功能、命名、注意与计算力、语言、抽象思维、定向力、延迟记忆各亚项及总分比较,均具有显著性差异,VMCI组明显低于对照组。VMCI组各亚项受损例次由高到底依次为:延迟记忆、语言、视空间与执行功能、抽象思维、注意与计算力、命名、定向力。VMCI组主要为3、4、5个亚项联合受损居多,而7个亚项全面受损和单个亚项受损所占比例很小。结论VMCI患者多为几个认知域联合下降,但不是认知域的全面下降。Objective To analyze the cognitive damage features of vascular mild cognitive impairment （VMCI）. Methods In reference to the international recognized NINDS - CSN in 2006 on the suggestions of the standards of vascular cognition impairment, the diagnostic criteria were implemented and the sensitive neuropsychological scale was detected. The professional physician of neurologic department screened VMCI patients（ VMCI group）and the peoples of normal cognition but with vascular dangerous factors in con- trol group. The cognition was compared between two groups. Results The significant differences presented between VMCI group and control group in the comparison of sub - item score and total score in MoCA visuospatial/executive ability, naming, attention/counting, language, abstraction, orientation and delayed recall. The outcomes in VMCI group were lower apparently than that in control group. The sequence of sub - item damage in VMCI group from high score to low one was delayed recall, language, visuospatial/executive ability, abstraction, attention/counting, naming and orientation. More cases in VMCI group had combined damages of sub - item 3,4 and 5. But the percentage was very small in overall damage of all 7 sub - items and single sub - item damage. Conclusion VMCI patients have mostly the combined decrease of several cognitive fields rather than overall cognitive decrease.

关 键 词：血管源性轻度认知障碍 认知损害 MOCA 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R742.7[医药卫生—临床医学]