表没食子儿茶素没食子酸酯的多靶点抗癌机理  

The inhibition of EGCG binding of multiple target molecules on carcinogenesis

作　　者：李嵬[1] 罗非君[1] 曹亚[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《生命的化学》2009年第6期784-788,共5页Chemistry of Life

摘　　要：蛋白质组学研究证明大量的靶蛋白质分子能与表没食子儿茶素没食子酸酯[(-)-epigallocatechin gallate,EGCG]直接相互作用,进而改变病变的肿瘤细胞的生理活动,产生抗癌作用。本综述阐述了EGCG与血浆、细胞膜、胞浆及细胞核中的不同靶分子直接结合的作用机制,为肿瘤化学预防与治疗提供了新的启发。Proteomic studies showed that a large set of protein targets can directly interact with （-）-epigallocatechin gallate （EGCG）, and EGCG can alter cellular physiology of tumor cells and is involved in antitumor activities. This review summarized the antitumor molecular mechanism of EGCG binding multiple target molecules from plasma membrane, cytoplasm and nucleus. It provides a new inspiration for chemical prevention of tumors.

关 键 词：表没食子儿茶素没食子酸酯 抗肿瘤 分子靶 化学预防 

分 类 号：R285[医药卫生—中药学]