肌肽与人类疾病  

Carnosine and human diseases

作　　者：贾慧婕[1] 那丽颖[1] 郑海霞[1] 周宏博[1] 

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,哈尔滨150081

出　　处：《生命的化学》2009年第6期913-917,共5页Chemistry of Life

基　　金：黑龙江省自然科学基金项目(D2007-13);黑龙江省教育厅科学技术研究项目(11541120)资助

摘　　要：肌肽是由丙氨酸和组氨酸组成的二肽,广泛存在于哺乳动物的肌肉、大脑和肾脏等组织中。研究表明,肌肽具有多种生物学活性,且与人类多种疾病密切相关。本文对肌肽在白内障、糖尿病、神经退行性疾病、肾脏疾病、消化道疾病、肝脏疾病和心脏疾病等疾病中的保护性作用做一综述。Carnosine （β-alanyl-L-histidine） is an endogenous synthesized dipeptide which is widely distributed in muscle, brain and kidney. In vitro and in vivo studies have revealed that carnosine possesses many biological functions such as cytosolic buffering capabilities, broad antioxidant activity, and metal ion-chelating properties. Recently, carnosine has been shown to relate closely to many of the human diseases. In this review, the application of carnosine in such diseases as cataract, diabetes, neurodegenerative disease, kidney diseases, diseases of digestive tract, liver diseases and heart diseases, was summarized.

关 键 词：肌肽 生物学活性 人类疾病 

分 类 号：R363[医药卫生—病理学]