Her2阳性乳腺癌中β-catenin和E-cadherin异常表达及其意义  

Abnormal expression of β-catenin and E-cadherin in Her2-positive breast cancer and its implications

作　　者：牛利刚[1] 何建军[1] 王珂[1] 张伟[1] 周灿[1] 

机构地区：[1]西安交通大学医学院第一附属医院肿瘤外科,陕西西安710061

出　　处：《南方医科大学学报》2009年第11期2237-2240,2243,共5页Journal of Southern Medical University

基　　金：陕西省科技攻关项目(2004K13-G5)

摘　　要：目的探讨人乳腺癌中Her2阳性表达与β连环蛋白(β-catenin)及上皮性钙粘素(E-cadherin)异常表达间的关系及意义。方法应用免疫组织化学方法检测147例乳腺癌中Her2、β-catenin和E-cadherin表达情况,同时检测19例癌旁正常乳腺和17例乳腺良性病变中β-catenin和E-cadherin的表达作为对照。结果在乳腺癌组织中,Her2阳性表达与腋窝淋巴结转移、较晚的临床分期及ER、PR阴性表达显著相关(P<0.05);β-catenin的异常表达与腋窝淋巴结转移和较高的组织学分级显著相关(P<0.01);E-cadherin的异常表达与腋窝淋巴结转移和较晚的临床分期显著相关(P<0.05);β-catenin的异常表达与E-cadherin的异常表达正相关(P<0.01);Her2的阳性表达与β-catenin的异常表达正相关(P<0.01),并且二者还协同促进了乳腺癌的腋窝淋巴结转移(P<0.01)。结论在人乳腺癌组织中Her2的阳性表达与β-catenin的异常表达呈正相关性,Her2的阳性表达与Wnt/β-catenin信号通路的异常激活之间可能存在功能上的相互联系。Objective To investigate the relationship between positive expression of Her2 and abnormal expressions of β-catenin and E-cadherin and its implications.Methods Immunohistochemistry was used to detect the expressions of Her2,β-catenin and E-cadherin in 147 samples of human breast carcinoma.The expressions of β-catenin and E-cadherin were also detected in 19 tissues adjacent to the carcinoma and 17 benign breast lesions as controls.Results In breast carcinoma,positive Her2 expression was associated with lymph node metastasis,advanced clinical stage and negative expression of ER and PR（P〈0.05）.Abnormal β-catenin expression was associated with positive lymph node status and high histological grade（P〈0.01）.Abnormality of E-cadherin expression was related to lymph node metastasis and advanced clinical stage（P〈0.05）.Abnormal β-catenin expression was directly correlated with abnormal E-cadherin expression（P〈0.01）.Her2 positivity showed a direct correlation to abnormal β-catenin expression（P〈0.01）,and they cooperated in promoting axillary lymph node metastasis in human breast carcinoma（P〈0.01）.Conclusion A direct correlation between positive Her2 expression and abnormal β-catenin expression exists in human breast carcinoma,and positive Her2 expression may have functional interactions with abnormal activation of Wnt/β-catenin signaling pathway.

关 键 词：Her2 Β连环蛋白 上皮性钙粘素 乳腺肿瘤 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]