Synthesis and cytotoxicity of novel podophyllotoxin derivatives  

作　　者：Yi Zheng YOU Guang Sun Yuan Zhang Jing Jing Lv Wen Chao Bi Yuan Wei Ma Hong Chen 

机构地区：[1]School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300191, China [2]Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China [3]TianJin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Tianjin 300162, China

出　　处：《Chinese Chemical Letters》2009年第12期1431-1434,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30873363);the Great Program of Science Foundation of Tianjin(No.09ZCKFNC01200);Program of Science Foundation of Tianjin (No.08JCYBJC070000).

摘　　要：In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3- yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro, KB and KBVusing MTT methods in vitro.In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3- yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro, KB and KBVusing MTT methods in vitro.

关 键 词：Podophyllotoxin derivatives CHEMOSYNTHESIS ANTITUMOR Multidrug resistance 

分 类 号：TQ463.2[化学工程—制药化工] Q959.133[生物学—动物学]