炎症反应影响脑缺血再灌注损伤的研究进展  

Inflammatory Reaction during Cerebral Ischemia Reperfusion Injury (review)

作　　者：刘秀平[1,2] 许栋明[3] 王文[1] 王烈群[2] 张丽[1] 艾厚喜[1] 李林[1] 

机构地区：[1]首都医科大学宣武医院,北京市100053 [2]内蒙古医学院,内蒙古呼和浩特市010059 [3]科技部火炬高技术产业开发中心,北京市100038

出　　处：《中国康复理论与实践》2009年第11期1041-1043,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：科技部"重大新药创制"科技重大专项(2009ZX09103-366);国家自然科学基金项目(30740053);北京市自然科学基金项目(7062031)

摘　　要：脑缺血再灌注损伤是脑损伤的因素之一,而局部过度炎症反应是造成再灌注损伤主要原因之一。许多炎症细胞及炎症介质均参与了炎症反应。本文主要综述炎症细胞、细胞因子、趋化因子、黏附分子等炎症因子对脑组织损伤的影响。The cerebral ischemia reperfusion injury is one of factors in aggravating brain injury,and the inflammatory response is one of the main reasons in the reperfusion injury after acute cerebral ischemia.Inflammation is modulated by many factors such as inflammatory mediators and inflammatory cells that promote brain damage from ischemia injury to reperfusion injury.This paper would review the role of inflammatory cells and mediators such as cytokines,chemotactic factors,adhesion molecules on cerebral tissue injury.

关 键 词：脑 缺血再灌注 白细胞 小胶质细胞 星型胶质细胞 细胞因子 趋化因子 黏附分子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]