PPARδ-87T/C基因多态性与糖代谢指标及肿瘤坏死因子浓度的研究  

Relationship of some indices of sugar metabolism with peroxisome proliferator-activated receptor delta polymorphism and TNFα level

作　　者：于晓静[1] 苏本利[2] 王晓梅[1] 冯海娟[1] 金成吉[1] 

机构地区：[1]大连大学附属中山医院内分泌科,辽宁大连116001 [2]大连医科大学附属第二医院内分泌科,辽宁大连116001

出　　处：《中国现代医学杂志》2009年第22期3395-3397,共3页China Journal of Modern Medicine

摘　　要：目的研究PPARδ-87T/C基因多态性与糖代谢相关指标及血浆肿瘤坏死因子浓度的关系。方法检测大连地区汉族人2型糖尿病(T2DM)组(286例)和空腹血糖正常(NFG)组(158例)的体重指数(BMI)、腰围、空腹血糖、血脂、胰岛素、肿瘤坏死因子浓度,以及PPARδ-87T/C基因多态性。结果T2DM组、NFG组基因型频率无统计学差异(P=0.012,P=0.994)。T2DM组,不同基因型间空腹血糖、体重指数、甘油三脂、胰岛素抵抗指数及血浆TNFα有统计学意义;NFG组中,不同基因型的空腹血糖及胰岛素抵抗指数有统计学意义。结论PPARδ-87T/C多态性与T2DM组的糖脂代谢、胰岛素敏感性及血浆TNFα相关;与NFG组胰岛素敏感性及空腹血糖相关。[ Objective ] To study the association of peroxisome proliferator-activated receptor delta-87T/C polymorphism with some indices of sugar metabolism and TNFα level. [ Methods ] Body mass index （BMI）, waist, fasting plasma glucose, serum lipid, fasting insulin, TNFαand polymorphism of peroxisome proliferator activated receptor deha-87T/C were measured in 286 cases of type 2 diabetes mellitus and 258 cases of normal fasting plasma glucoses in Dalian Chinese people. [ Results ] There were no differences in the distrubution of genotypic frequencies between T2DM and NFG （P =0.012, P =0.994）. BMI, FBG, HOMA-IR, triglyceride and TNFα have a significant difference of different genotypes in T2DM. HOMA-IR and FBG have significant difference of different genotypes in NFG. [Conclusion] The polymorphism of PPAR delta-87T/C has relationship with level of glucose and lipid metabolism, HOMA-IR and TNFα level in T2DM as well as HOMA-IR and FBG in NFG.

关 键 词：过氧化物酶体增殖物激活受体Δ 2型糖尿病 多态性 肿瘤坏死因子浓度 

分 类 号：R781.64[医药卫生—口腔医学]