阿尔茨海默病长潜时视觉和听觉诱发电位改变  

The variations of long latency visual and auditory evoked potentials in patients with Alzheimer′s disease

作　　者：陈兴时[1,2] 张明岛[1,2] 楼翡璎[1,2] 王继军 梁建华[1,2] 郭起浩 张明园[1,2] 

机构地区：[1]上海市精神卫生中心 [2]上海医科大学

出　　处：《中华精神科杂志》1998年第4期199-201,共3页Chinese Journal of Psychiatry

摘　　要：目的探讨阿尔茨海默病（ＡＤ）患者的长潜时感觉性诱发电位的特点。方法应用丹麦电生理仪以及光和声刺激，对３９例ＡＤ患者和４０名正常老年人的视觉诱发电位（ＶＥＰ）和听觉诱发电位（ＡＥＰ）进行对照研究。结果部分ＡＤ患者ＶＥＰ形成双峰，ＡＥＰ趋向低而宽大。ＡＤ患者ＶＥＰ和ＡＥＰ的Ｐ３潜伏期在顶区均右侧（ＶＥＰ３７７±４４毫秒，ＡＥＰ３８８±２７毫秒）长于左侧（ＶＥＰ３７２±４４毫秒，ＡＥＰ３８１±２６毫秒），Ｐ＜０．０５。与对照组比较，ＡＤ患者ＡＥＰ主成分以及ＶＥＰ的Ｐ３潜伏期和ＡＥＰ、ＶＥＰ的Ｐ２、Ｐ３波幅均延迟和下降（Ｐ＜０．０５或＜０．０１）。Objective To investigate the variations of long latency auditory evoked potential (AEP) and visual evoked potential (VEP) in patients with Alzheimer′s disease (AD). Methods Both AEP and VEP were elicited from 39 patients definitely diagnosed as Alzheimer′s disease and 40 normally age matched subjects by presenting them auditory and visual stimuli, using a Dantec Concerto SEEG 16 Instrument. Results A double peak waveform of VEP was found in some AD patients. The AEP of AD patients presented a plain and wide waveform. No significant difference was found between the results recorded at Fz, Cz and Pz ( P >0.05). A longer AEP P 3 latency was found at C 4 than at C 3 in AD patients ( P <0.05). Compared with the controls, AD patients showed a prolonged P 3 latency, decreased P 2 and P 3 amplitudes at both AEP and VEP ( P <0.05 or P <0.01). Conclusion The 50～500 ms components of AEP and VEP could reflect the cognitive dysfunction of Alzheimer′s disease.

关 键 词：早老性痴呆 视觉诱发电位 听觉诱发电位 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学]