bcl-2基因在人脑星形细胞瘤组织表达的研究  

INVESTIGATION OF bcl 2 GENE EXPRESSION IN HUMAN BRAIN ASTROCYTOMA

作　　者：赵文元[1,2] 王文仲[1,2] 周晓平 赵孟尧[1,2] 向正华 

机构地区：[1]第二军医大学长海医院神经外科 [2]第二军医大学基础部组胚教研室

出　　处：《肿瘤》1998年第6期389-390,共2页Tumor

摘　　要：目的探讨人脑星形细胞瘤发生、发展及预后的分子生物学基础。方法应用原位分子杂交技术检测了３４例人脑星形细胞瘤组织中ｂｃｌ┐２基因ｍＲＮＡ表达情况。结果ｂｃｌ┐２表达阳性率分别为Ｉ级星形细胞瘤５／８、ＩＩ级星形细胞瘤７／１２、Ⅲ～Ⅳ级星形细胞瘤６／１４。结论ｂｃｌ┐２是人脑星形细胞瘤常见被激活的凋亡抑制基因，对人脑星形细胞瘤的发生。Objective:To explore the molecular biological mechanism of genesis,progress and prognosis in human brain astrocytoma.Methods:Thirty four cases of astrocytoma were detected for bcl 2 gene mRNA expression with a technique of in situ hybridyzation.Results:bcl 2 gene expression was found 5/8 in Grade I cases,7/12 in Grade II cases and 6/14 in Ⅲ～Ⅳ cases.Conclusion:bcl 2 gene is commonly activated in human brain astrocytoma and plays an important role in its genesis,progress and prognosis.

关 键 词：星形细胞瘤 BCL-2 细胞凋亡 

分 类 号：R730.264[医药卫生—肿瘤]