老年性痴呆患者认知功能与磁共振成像  

A correlative study on early cognitive changes and brain MRI linear measurements in Alzheimer′s disease

作　　者：刘军生[1,2,3] 王鲁宁[1,2,3] 蔡剑鸣[1,2,3] 蔡幼铨 崔屹[1,2,3] 卢文甫 

机构地区：[1]解放军总医院老年神经科 [2]天津解放军272医院 [3]北京邮电大学

出　　处：《中华内科杂志》1998年第11期733-733,共1页Chinese Journal of Internal Medicine

摘　　要：目的观察老年性痴呆病（ＡＤ）患者临床神经心理学变化和海马体积改变相关性意义。方法对３２例ＡＤ病人行ＭＲＩ冠状位扫描，用计算机图像定量分析技术测量海马体积（ＨＰＶ）；从ＭＲＩ片上测出海马结构（ＨＦ）和脉络膜间隙（ＣＦ）结构线性比值（ＨＦ／ＣＦ）；与神经心理学检测评分进行相关性统计；同时与正常人对比。结果ＡＤ病人ＨＰＶ、ＨＦ／ＣＦ均小于对照组（Ｐ＜０．００１）。ＨＰＶ、ＨＦ／ＣＦ同侧比较均有明显相关性（ｒ＝０．７７～０８２）。两侧ＨＰＶ、ＨＦ／ＣＦ与记忆商数（ＭＱ）、简易智力测验评分也有明显相关性，尤以ＭＱ最为明显（０７５～０７８，Ｐ＜０．０１）。结论轻度ＡＤ患者即有海马结构萎缩。用简易方法直接阅ＭＲＩ片测算ＨＦ／ＣＦ，同样能够对ＡＤ病人的海马结构加以评估。Objective To observe the correlation between clinical neuropsychological changes and hippocampal volume (HPV) changes in Alzheimer′s disease (AD). Through direct reading of MRI film, early changes of hoppocmpal formation (HF) in AD were found. Methods Thirty two AD patients and a group of controls were examined with coronal MRI scans. HPV was determined with computer image measurement analytic technique and the linear ratio of HF and choroid fissure (HF/CF) measured according to the MRI films. A correlative statistic analysis between HF/CF and scales of neuropsychological test was done. Results HPV and HF/CF in AD were less than those in the control group ( P <0.001). HPV and HF/CF had a significant correlative relationship on the same side ( r =0.77～0.82). HPV, HF/CF and memory quotient (MQ), with MQ the most significant ( r =0.75～0.78, P <0.01). Conclusion It is suggested that AD patients in early stage have HF atrophic changes. By direct reading of MRI film and estimating the ratio of HF/CF, early changes of HF in AD patients can be evaluated and these changes will provide the basis for early clinical diagnosis of AD.

关 键 词：老年性痴呆 NMR 成像 海马 认知功能 诊断 

分 类 号：R749.160.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]