血清TGF-β_1在晚期非小细胞肺癌三维适形放疗中的临床意义  

Detection of serum TGF-β_1 in patients with non-small-cell lung cancer after and before 3-dimensional conformal radiotherapy

作　　者：耿丽[1] 刘占伟[1] 张永亮[1] 申国宏 石磊[1] 杨曦[1] 

机构地区：[1]武警山西总队医院综合科,太原030006

出　　处：《武警医学》2009年第11期1022-1024,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的了解晚期非小细胞肺癌(NSCLC)患者血清TGF-β_1的意义,以及TGF-β_1在晚期NSCLC患者三维适形放疗前后的变化。方法比较78例晚期NSCLC患者与78例对照组健康正常人的血清TGF-β_1的浓度,再观察78例晚期NSCLC患者放疗前以及放疗后4周血清TGF-β_1浓度变化。结果晚期NSCLC患者放疗前血清中TGF-β_1的浓度与对照组比较明显升高。晚期NSCLC患者腺癌组血清中TGF-β_1浓度较鳞癌组高(P<0.05)。晚期NSCLC患者放疗后血清中TGF-β_1的浓度较放疗前低(P<0.05)。结论晚期NSCLC患者血清TGF-β_1浓度在不同组织学类型中的表达是不同的。动态检测晚期NSCLC患者血清中TGF-β_1浓度水平可能有助于三维适形放疗效果的评价。Objective To investigate the changes and clinical assessment of transforming growth factor β1 （TGF - β1 ） in patients with non - small - cell lung cancer （NSCLC） before and after 3 - dimensional conformal radiotherapy. Methods The levels of serum TGF - β in 78 patients with NSCLC and 78 healthy control subjects were detected by ELISA ; the data of 78 patient with NSCLCwere analyzed and compared with those of control group. Results The TGF - β1 level in serum of NSCLC patients was significantly higher than that in control group （ P 〈 0. 05 ）. There was a significant differ-ence in the TGF - β1 level in patients with NSCLC before and after 3 - dimensional conformal radiotherapy. （ P 〈0.05 ）. Conclusion Higher levels of serum TGF-β1 may be related to the pathogenesis and development of lung cancer,and serum TGF- β1 can be used as one of diagnostic and efficacy indicators in NSCLC patients undergoing radiotherapy.

关 键 词：非小细胞肺癌 TGF—β1 三维适形放疗 

分 类 号：R734.2[医药卫生—肿瘤]