银杏叶提取物(EGb)对大鼠局部脑缺血及颈动脉血栓形成的保护作用  

PROTECTIVE EFFECTS OF GINKGO BILOBA EXTRACT ON FOCAL CEREBRAL ISCHEMIA AND THROMBOGENESIS OF CAROTID ARTERY IN RATS

作　　者：张玉珍[1,2] 顾德官[1,2] 茅守玉 陈维洲[1,2] 

机构地区：[1]上海第二医科大学附属瑞金医院上海市高血压研究所 [2]中国科学院上海药物研究所

出　　处：《药学学报》1998年第12期901-905,共5页Acta Pharmaceutica Sinica

摘　　要：应用大鼠大脑中动脉梗塞和血栓形成导致缺血性脑卒中的实验模型，观察银杏叶提取物（ＥＧｂ）对脑缺血面积和由缺血造成的行为障碍的影响。结果表明预防或治疗性ｉｖ大剂量ＥＧｂ（２００ｍｇ·ｋｇ－１）均能显著减少脑缺血面积，明显改善大鼠脑缺血造成的行为障碍，其预防作用似优于治疗作用。预防性ｉｖ小剂量ＥＧｂ（１００ｍｇ·ｋｇ－１）也能明显减少血栓形成性脑缺血面积，改善梗塞和血栓形成性脑缺血所致的行为障碍，与阳性对照药尿激酶和尼莫地平作用相同。实验还发现ＥＧｂ有抑制大鼠电刺激颈总动脉的血栓形成的作用，且其对抗血栓形成强度具剂量依赖性。提示ＥＧｂ对缺血性脑卒中和血栓形成有预防和治疗作用。Rat focal cerebral ischemia induced by occlusion and thrombogenesis of middle cerebral artery(MCAO) was used as experimental model to study the effects of extract of Ginkgo biloba (EGb) and the positive control drugs were urokinase and nimodipine on cerebral infarct size and neurological deficits. The results showed that cerebral ischemia and neurological deficits appeared in rat focal cerebral ischemic models, and the degree was of cerebral ischemia larger in occlusion model than in thrombogenesis model. The cerebral infarct size was significantly smaller and neurological deficits greatly improved at large dose of EGb(200 mg·kg -1 , iv), the preventive effect appeared to be better than the treatment effect. The positive control drugs urokinase and nimodipine were also shown to distinctly decrease the cerebral infarct size and inprove the neurological deficits in the models. Small dose of EGb(100 mg·kg -1 , iv) was found to decrease the cerebral infarct size of thrombogenesis model, and improve neurological deficits of both thrombogenesis and occlusion model. EGb was also shown to inhibit the thrombogensis of rat common carotid artery stimulated by electrical current in dose dependent manner. This experiment indicates that EGb might have beneficial effects on prevention and treatment of ischemic stroke and thrombogenesis.

关 键 词：大脑中动脉 银杏叶提取物 抗血栓 脑缺血 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R931.71[医药卫生—临床医学]