肺癌患者红细胞CR1基因密度型分布与红细胞免疫变化的研究  

Distribution of erythrocyte CR1 genomic density polymorphism and changes of erythrocyte immunity in pulmonary cancer patients

作　　者：王若霞[1,2] 郭峰[1,2] 张俊洁 赵书平[1,2] 

机构地区：[1]解放军第476医院内科 [2]上海第二军医大学附属长海医院免疫室

出　　处：《中华微生物学和免疫学杂志》1998年第6期479-481,共3页Chinese Journal of Microbiology and Immunology

摘　　要：目的检测３２例肺癌患者红细胞ＣＲ１基因密度型分布、红细胞免疫粘附肿瘤细胞功能及ＳＯＤ酶活性、β－内啡肽含量。方法ＰＣＲ法检测红细胞ＣＲ１基因密度多态性；红细胞花环法检测红细胞免疫粘附肿瘤细胞能力；放免法测定ＳＯＤ酶活性；ＲＩＡ法测定β－内啡肽含量。结果经与３１例正常人比较显示：肺癌患者ＣＲ１基因密度多态性分布与正常人不一致（χ２＝３．１９，Ｐ＜０．０５）；红细胞免疫功能及ＳＯＤ酶活性较正常人明显降低（Ｐ＜０．０１）；β－内啡肽较正常人明显升高（Ｐ＜０．０１）。同时还发现肺癌患者的红细胞粘附肿瘤细胞功能与ＳＯＤ酶活性呈正相关（ｒ＝０．３９．Ｐ＜０．０５）。结论肺癌患者红细胞免疫功能低下；ＳＯＤ酶活性降低；The distribution of erythrocyte CR1 density gene types,erythrocyte immune adhesion tumour cell function,SOD activity, concentration of β endorphin in 32 cases with pulmonary cancer were measured and compared with 31 cases of normal control group.The results showed the multiple distribution of erythrocyte CR1 density gene types in pulmonary cancer patients were different from normal control group( χ 2=3.91, P <0.05).The erythrocyte immune function and SOD activity were significantly decreased,but the concentration of β endorphin were significantly elevated ( P <0.01),as well as there was a positive correlation between erythrocyte immune adhesion tumour cell function and SOD activity in pulmonary cancer patients( r =0.39, P <0.05).These results suggested that all erythrocyte immune function decreased,SOD activity decreased and elevation of β endorphin had partial relationship to the changes of erythrocyte CR1 density gene types.

关 键 词：肺肿瘤 红细胞免疫 CR1基因密度 SOD Β内啡肽 

分 类 号：R734.203[医药卫生—肿瘤]