ω-3多不饱和脂肪酸在老年胃癌病人术后肠外营养中的应用  

The effect of omega-3 polyunsaturated fatty acids on elder patients after gastric cancer operation

作　　者：魏玉哲[1] 宋洪江[1] 王佳[2] 王铁[1] 蓝秀文[1] 薛英威[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院胃肠外科,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院妇三科,黑龙江哈尔滨150081

出　　处：《肠外与肠内营养》2009年第6期328-331,共4页Parenteral & Enteral Nutrition

摘　　要：目的:研究在老年病人胃癌根治术后肠外营养(PN)中应用ω-3多不饱和脂肪酸(ω-3 PUFA)的作用。方法:将40例老年胃癌切除术后病人随机分为试验组和对照组,每组20例。对照组病人按低氮、低热量原则给予PN治疗,试验组加用ω-3 PUFA。比较两组病人营养指标、免疫指标、肝功能变化、炎性反应指标和并发症的发生率等。结果:试验组病人并发症的发生率为5%,对照组为20%,差异有显著性意义(P<0.05)。术后经5 d的治疗,试验组病人PA水平、体液免疫和细胞免疫指标、IgA、IgG含量和CD4细胞均显著高于对照组(P<0.05,P<0.01)。两组病人术后第1天IL-6、TNF-α和CRP水平均升高。第5天后,试验组IL-6、TNF-α和CRP显著低于对照组(P<0.05)。对照组病人肝功指标明显升高,与试验组相比有显著性差异(P<0.05)。结论:ω-3 PUFA可通过阻断过度炎性反应、调节病人免疫功能和保护器官功能等作用,有利于老年胃癌病人术后的康复。Objective：To investigate the clinical effect of ω-3 polyunsaturated fatty acids （ω-3 PUFA） on elder patients after gastric cancer radical operation. Methods： Forty patients were randomly divided into experimental group（EG） and control group（CG）, The patients of CG were treated with hypocalorie and lower nitrogen parenteral nutrition, and those in EG received ω-3 PUFA additionally. The nutrition index, immune function, liver function, inflammatory reaction and complications were compared. Results： The rate of complications significantly decreased in the EG （20% vs 5%, χ^2 = 3. 958, P 〈 0.05）. There were no significant differences in albumn and hemoglobin between the two groups （P 〉 0.05 ）. The level of prealbumin was significantly increased in the EG. The humoral immunity and cellular immunity were higher in the EG than those in the CG. IL-6, TNF-α and CRP levels on postoperatiw, d5 were significantly depressed in the EG. Conclusion： Postoperative supplementation of ω-3 PUFA may have a favorable effect on the outcomes in elder gastric cancer patients.

关 键 词：胃癌 Ω-3脂肪酸 免疫功能 

分 类 号：R735.2[医药卫生—肿瘤]