Prion疾病疫苗研究策略  

Strategies of Vaccines against Prion Disease

作　　者：郭燕[1] 董小平[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室,北京市100052

出　　处：《医学分子生物学杂志》2009年第6期534-537,共4页Journal of Medical Molecular Biology

基　　金：资助项目：国家科技支撑项目（No.2006BAD06A13-2）,国家重点基础研究发展规划项目（973计划）（No.2007CB31050-5）、国家自然科学基金（No.30571672,30500018,30771914）

摘　　要：朊病毒病是一类侵袭人类及多种动物中枢神经系统的致死性退行性脑病，目前缺乏有效的预防和治疗方法。朊病毒病的重组蛋白亚单位疫苗、DNA疫苗、合成肽疫苗、病毒样颗粒疫苗、树突状细胞疫苗、黏膜免疫疫苗等已取得一定进展，但现有的免疫策略仅能部分克服免疫耐受，诱导较低或中等滴度的抗体，对PrPSc感染动物模型只能提供部分保护，Prion疫苗研究任重而道远。Prion diseases are fatal neurodegenerative disorders which can be acquired by human and many kinds of animals. At present, there are no effective preventive and therapeutic meth- ods. Recombinant protein subunit vaccine, DNA vaccine, synthetic peptide vaccine, viral like par- ticles, dendritic cell vaccine and musocal vaccine against Prion diseases have achieved certain pro- gress. However, strategies used now can only partially overcome immune tolerance, induce only low and moderate degree of antibody, and provide inadequate protection in animal models. Therefore, strategy of vaccines against Prion diseases is thorny but imminent.

关 键 词：朊病毒病 重组蛋白亚单位疫苗 DNA疫苗 合成肽疫苗 病毒样颗粒疫苗 

分 类 号：R186.9[医药卫生—流行病学]