早期鼻咽癌血管内皮细胞生长因子表达与肿瘤组织^(18)F-FDG摄取的关系  

Relationship between fluorodeoxyglucose uptake and vascular endothelial growth factor in early-stage nasophygeal carcinoma

作　　者：范义湘[1] 石卫民[2] 黎静[3] 尹吉林[4] 杨传红[5] 高梅菊[1] 吴继珍[1] 刘青竹[1] 李科斌[1] 

机构地区：[1]广东省第二人民医院核医学科,广东广州510317 [2]广东省第二人民医院肿瘤一科,广东广州510317 [3]广州军区广州总医院肿瘤科,广东广州510010 [4]广州军区广州总医院核医学科,广东广州510010 [5]广州军区广州总医院医学实验科,广东广州510010

出　　处：《南方医科大学学报》2009年第10期2067-2069,共3页Journal of Southern Medical University

摘　　要：目的研究早期鼻咽癌组织血管内皮细胞生长因子(VEGF)表达及肿瘤组织18F-FDG摄取的情况,并探讨早期鼻咽癌组织VEGF表达与18F-FDG摄取的关系。方法对40例I,II期鼻咽癌患者进行正电子发射体层显像检查,测定鼻咽原发灶肿瘤组织的18F-FDG最大摄取值和标准摄取值(SUVmax和SUVmean),应用标准链霉菌抗生物素蛋白-过氧化物酶亲和免疫组化法检测40例患者肿瘤组织VEGF的表达。结果40例早期鼻咽癌组织的SUVmax与SUVmean分别为9.45±1.87和6.04±1.09,T1期肿瘤原发灶SUVmax与SUVmean分别为8.95±1.91和5.61±1.08,T2期的原发灶SUVmax与SUVmean分别为11.55±1.70和7.98±1.1,T2期原发灶SUVmax和SUVmean高于T1期(t=4.46,P<0.001;t=6.763,P<0.001)。非角化分化型肿瘤原发灶SUVmax与SUVmean分别为9.74±1.82和6.82±1.23,非角化未分化型肿瘤原发灶SUVmax与SUVmean分别为10.44±2.16和6.68±1.35,非角化分化型和非角化未分化型肿瘤原发灶SUVmax和SUVmean无差别(t=1.230,P>0.05;t=0.346,P>0.05)。40例鼻咽癌组织VEGF染色阳性细胞率为60.8%;鼻咽癌组织FDG摄取(SUVmax)和VEGF表达的细胞阳性率相关(r=0.460,P=0.03)。结论早期鼻咽癌组织FDG摄取与肿瘤组织VEGF过度表达相关,其SUV值反映了鼻咽癌组织的葡萄糖代谢情况,同时也在一定程度上反映了肿瘤组织乏氧的程度。Objective To study the overexpression of vascular endothelial growth factor （VEGF） and fluorine-18 fluorodeoxyglucose （FDG） uptake in early-stage nasopharyngeal carcinoma （NPC） and evaluate their relationship. Methods FDG positron emission tomography （PET） was performed in forty patients with stage I and stage II NPC. The maximum and mean standard uptake values （SUVmax and SUVmax, respectively） were measured in each patient, and the expression of VEGF was measured on paraffin sections using immunohistochemistry. Results The FDG uptake in the patients were 9.45±1.87 （SUVmax） and 6.04±1.09 （SUVmax）, 8.95±1.91 （SUVmax） and 6.04±1.09 （SUVmax） in stage I patients, and 11.55±1.70 （SUVmax） and 7.98-＋1.1 （SUVmax） in stage II patients. The FDG uptake of stage II patients was higher than that of stage I patients. The FDG uptake of non-keratinizing differentiated carcinoma was 9.74±1.82 （SUVmax and 6.82±1.23 （SUVmax） and 10.44±2.16 （SUVmax） and 6.68±1.35 （SUVmax） in non-keratinizing undifferentiated carcinoma, showing no significant differences between them （SUVmax t=1.230,P〉0.05; SUVmax t=0.346, P〉0.05）. The VEGF-positive cells were 60.80% in the tumor. A correlation between VEGF expression and FDG uptake in he tumor was noted （r=0.460, P=-0.03）. Conclusion VEGF overexpression is correlated to FDG uptake in patients with early-stage NPC. The SUV value refects the glucose metabolism of NPC, and also shows the degree of oxygen insufficiency in the tumor tissue.

关 键 词：鼻咽肿瘤 血管内皮生长因子 FDG 放射性示踪剂 体层摄影术 发射型计算机 

分 类 号：R739.63[医药卫生—肿瘤]