210例髓母细胞瘤临床病理研究及预后因素分析  

Clinicopathological and Prognostic Factor Analysis in 210 Cases of Medulloblastoma

作　　者：张庆慧[1] 苏晓萍[1] 梁思泰[1] 李红[1] 谭燕泉[1] 孙鸿铖[1] 

机构地区：[1]山东医科大学病理学研究室,济南市250012

出　　处：《中国肿瘤临床与康复》1998年第4期4-6,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 :分析髓母细胞瘤 (MB)的临床病理特点及影响预后的因素。方法 :对 33年间病理证实的 2 10例 MB进行组织学及免疫组织化学观察。采用 L og- rank检验进行预后分析。结果 :MB病人术后 1年、3年及 5年生存率分别为 34.6 5 %、13.77%和 10 .71% ,平均生存 2 2个月。与病人生存期延长的有关因素为病人年龄≥ 18岁 (P=0 .0 44 4)、促纤维增生型 MB(P=0 .0 317) PCNA标记指数低 (P=0 .0 2 2 7)、肿瘤无灶状坏死 (P=0 .0 0 0 2 )及术后接受放射治疗 (P=0 .0 0 0 1)。性别、术前病程长短、肿瘤大小、部位及分化程度与病人预后无明显关系。结论 :年龄、组织类型、细胞增殖活性、肿瘤灶状坏死及术后放疗是与 MB病人预后有关的重要因素。Objective:To study the clinicopathological features and evaluate the effect of various factors on survival in medulloblastoma.Methods:210 cases of cerebellar medulloblastoma were observed with histological and immunohistochemical methods.Difference in survival among groups was analyzed by the log rank test.Results:The median time of survival after operation was 22 months.The overall 1,3,5 year survival rate were 34.63%,13.77% and 10.71% respectively.Significant factors in predicting a longer postoperative survival were age>18 year (P=0.0444),desmoplastic type (P=0.0317),lower proliferative index (P=0.0227),no focal necrosis in tumor (P=0.0002),and receiving radiation Therapy after operation (P=0.0001).Other factors such as sex,size, location and differentiation of tumor had no effect on prognosis.Conclusion:Age,histological type,proliferative index,focal necrosis and post operative craniospinal irradiation in medulloblastoma are significant prognostic factors.

关 键 词：髓母细胞瘤 病理学 增殖细胞核抗原 预后 

分 类 号：R739.410.2[医药卫生—肿瘤]