经PET-CT检测胃肠道^(18)F-FDG高摄取的内镜分析  

Endoscopic analysis of the ^(18)F-FDG accumulations in gastrointestinal tract after PET-CT examinations

作　　者：张召珍[1] 贺益萍[1] 沈俊[1] 

机构地区：[1]复旦大学附属肿瘤医院内镜科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2009年第11期842-845,共4页China Oncology

摘　　要：背景与目的:18F-FDG是PET-CT检测中最常用的示踪剂,是肿瘤显像中应用的标准的影像模式之一,但18F-FDG的摄取并不具有肿瘤特异性。为此,本研究旨在探讨对经PET-CT检测后胃肠道18F-FDG高摄取的病例进行内镜检查的价值。方法:对临床上33例胃肠道18F-FDG高摄取的病例的内镜及病理诊断结果进行分析。结果:经内镜检查,在33例胃肠道18F-FDG高摄取的病例中,胃肠道恶性肿瘤14例,其中食管癌2例,胃癌5例,结直肠癌7例;癌前病变8例,其中腺瘤性息肉4例,增生性息肉1粒,Barrett食管1例,糜烂性胃炎2例;炎症性病变6例,其中活动性肠炎5例,吻合口瘘1例;无异常发现5例。PET-CT的假阳性率为(11/33)33.33%。结论:对胃肠道18F-FDG高摄取的病例进行内镜下确诊具有非常重要的意义。Background and purpose： The radio-labeled glucose analogue F-18-fluoro-2-deoxyglucose （FDG） is the most widely used tracer in PET imaging, and its application in oncology has become one of the standard imaging modalities. But FDG uptake is not tumor specific. The aim of this paper was to study the endoscopic result with the patients of 18F-FDG accumulations in gastrointestinal tract after PET-CT examinations. Methods： Thirty- three patients with 18F-FDG accumulations in gastrointestinal tract were correlated with endoscopic and histopathologic results. Results： Of these, 14 patients were harboring newly occurring cancers in gastrointestinal tract （esophagus cancer, 2 patients; gastric cancer,5 patients; colorectal cancer, 7 patients）. Eight patients were identified with precancerous lesions （adenoma, 4 patients; hyperplastic polyp, 1 patient; Barrett＇s esophagus, 1 patient; intestinal metaplasia of the gastric mucosa, 2 patients）. Inflammatory lesions were detected in six patients （active colitis, 5 patients; anastomotic leakage, 1 patient）. In five patients, PET/CT showed normal findings in endoscopic examinations. The false positive rate of PET-CT was 33.33% （11/33）. Conclusion： Endoscopic result is important for patients of 18F-FDG accumulations in gastrointestinal patient.

关 键 词：内镜 体层摄影术 发射型计算机 胃肠道 氟脱氧葡萄糖 

分 类 号：R730.42[医药卫生—肿瘤]