Adenoviral transduction of PTEN induces apoptosis of cultured hepatic steUate cells  

作　　者：HAO Li-sen ZHANG Xiao-lan AN Jun-yan YAO Dong-mei Justin Karlin FANG Shu-ming JIANG Hui-qing BAI Wen-yuan CHEN Shuang 

机构地区：[1]Department of Gastroenterology, Second Hospital of HebeiMedical University, Hebei Key Laboratory of Gastroenterology,Hebei Institute of Gastroenterology, Shijiazhuang, Hebei 050000,China [2]Department of Pediatric, UCLA Medical School, Cedars-SinaiMedical Center, Los Angeles, CA, 90048, USA

出　　处：《Chinese Medical Journal》2009年第23期2907-2911,共5页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China （No. 30872513）.

摘　　要：Hepatic fibrosis is the liver＇s wound healing response to virtually all forms of chronic liver injury： toxic insult, viral infection, immunological conditions and metabolic diseases. Uncontrolled liver fibrosis eventually results in cirrhosis and associated complications, such as cancer and liver failure. Given the enormous public health implications, recent improvements in the treatment of chronic liver disease have accelerated interest in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Currently, it is believed that activation of quiescent hepatic stellate cells （HSC） into proliferative, contractile, and fibrogenic cells in response to liver injury appears to be the dominant driving force in fibrosis.Hepatic fibrosis is the liver＇s wound healing response to virtually all forms of chronic liver injury： toxic insult, viral infection, immunological conditions and metabolic diseases. Uncontrolled liver fibrosis eventually results in cirrhosis and associated complications, such as cancer and liver failure. Given the enormous public health implications, recent improvements in the treatment of chronic liver disease have accelerated interest in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Currently, it is believed that activation of quiescent hepatic stellate cells （HSC） into proliferative, contractile, and fibrogenic cells in response to liver injury appears to be the dominant driving force in fibrosis.

关 键 词：PTEN protein hepatic stellate cells FIBROSIS APOPTOSIS 

分 类 号：Q255[生物学—细胞生物学] Q253