肾移植术后恶性肿瘤:14例病例  

Malignancies after kidney transplantation:Analysis of 14 Cases

作　　者：王海[1] 纪志刚[1] 薛翀[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院泌尿外科,北京100730

出　　处：《癌症进展》2009年第6期665-668,共4页Oncology Progress

摘　　要：目的总结肾移植术后恶性肿瘤的发生率、发生机制及治疗方法。方法回顾性分析我院1991～2006年间500例肾移植后并发恶性肿瘤的诊断、治疗情况。结果14例病例发生恶性肿瘤,占肾移植病例总数的2.8%。治疗方法包括:停用或减少部分免疫抑制剂的用量,更换免疫抑制剂的种类;手术切除肿瘤,辅以化疗和放疗。后者转归较佳。讨论要重视肾移植后病人发生肿瘤的问题。肾移植后个体化监测及治疗对术后并发恶性肿瘤患者有较大的帮助。To analyze the incidence and pathogenesis of various de novo malignancies in renal transplant recipients and to investigate their pathogenesis and treatment options. Methods We retrospectively analysed 500 cases of patients who received renal transplantation in PUMC Hospital between 1991 and 2006. Emphasis is placed on the surveillance method, choice of treatment, and prognosis. Results Fouteen of the 500 patients developed malignancies, giving an incidence of 2. 8%. In some cases the immunosuppressive drugs were discontinued. Others received surgical resection of the tumor and adjective chemotherapy and/or radiotherapy. The prognosis was more promising in the latter group. Discussion The surveillance method of patients after renal transplantation should be individualized to achieve maximum benefits for patients.

关 键 词：肾移植 恶性肿瘤 

分 类 号：R737[医药卫生—肿瘤]