激素和生长因子对人牙乳头细胞骨钙素合成分泌的影响  

Effects of 1,25(OH) 2D 3, Insulin , EGF and TGF-β on the osteocalcin secretion of human dental papilla cells in vitro

作　　者：赵大为[1] 史俊南[1] 陈建元[1] 

机构地区：[1]西安第四军医大学口腔医学院

出　　处：《牙体牙髓牙周病学杂志》1998年第4期258-259,共2页Chinese Journal of Conservative Dentistry

摘　　要：目的：探讨激素和生长因子对人牙乳头细胞骨钙素合成分泌的影响；方法：采用放射免疫的方法进行测定。结果：１，２５（ＯＨ）２Ｄ３对骨钙素的合成分泌具有明显增强作用，胰岛素、ＥＧＦ对其合成有促进作用，但较弱。而ＴＧＦ－β抑制骨钙素的合成分泌。结论：人牙乳头细胞合成分泌骨钙素受这些因子不同程度的影响。Aim: To study the effects of 1,25(OH) 2D 3, Insulin , EGF and TGF-β on the osteocalcin secretion of human dental papilla cells in vitro. Methods:A radioimmunological method was used to determine the osteocalcin secrection by the human papilla cells. Results: 1,25(OH) 2D 3 could stimulate osteocalcin secretion dramatically, but TGF-β inhibited its secretion. Conclusions: These results suggested that these factors may act as regulators of osteocalcin secretion of human dental papilla cells in vitro.

关 键 词：人牙乳头细胞 骨钙素 细胞培养 放射免疫 

分 类 号：R780.2[医药卫生—口腔医学]