生物反馈结合线索暴露治疗降低海洛因依赖者药物线索反应  被引量:5

Combination of Biofeedback Therapy and Cue-exposure Therapy Decreased Heroin-related Cue Reactivity in Abstinent Heroin Dependents

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作  者:范成路[1,2] 赵敏 杜江[1] 陈晗晖[1] 孙海明[1] 袁颖[1] 陈莉敏[1] 江海峰 王兆薇[1] 

机构地区:[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]沈阳军区大连疗养院第二一五临床部,辽宁大连116041

出  处:《中国心理卫生杂志》2009年第12期856-860,共5页Chinese Mental Health Journal

基  金:美国N IH/F IC资助(R01TW007279);上海市申康医院发展中心适宜技术联合开发推广应用项目(SHDC12007223);上海市禁毒基金(0601)

摘  要:目的:了解生物反馈结合线索暴露治疗是否降低海洛因依赖者环境线索诱发渴求及心理生理反应。方法:采用前瞻性的队列研究将60例环境线索诱发心理渴求增高的康复期海洛因依赖者分成实验组(n=36)与对照组(n=24),对照组只进行劳教场所的常规帮教,实验组除帮教外进行12次生物反馈结合线索暴露治疗,评估治疗前后环境线索诱发心理渴求与心理生理反应情况。结果:两组治疗结束后,实验组环境诱发前、后的心理渴求,肌电和皮导得分均低于对照组[诱发前:心理渴求(3.06±7.26)mm vs.(22.32±20.26)mm、肌电(8.52±4.23)μV vs.(12.06±5.17)μV、皮导(2.14±1.43)μS vs.(4.61±2.24)μS;诱发后:心理渴求(6.97±10.30)vs.(33.14±25.40)mm、肌电(8.72±4.31)vs.(14.79±5.86)μV、皮导(2.15±1.33)vs.(4.49±2.59)μS,P≤0.01]。结论:生物反馈结合线索暴露治疗可降低康复期海洛因依赖者渴求及环境诱发心理生理反应。Objective: To understand whether or not biofeedback therapy ( BT) and cue- exposure therapy ( CET) could decrease craving and heroin-related cue reactivity in abstinent heroin dependents. Methods: Adopting stratified sampling means, 60 abstinent heroin dependents whose craving increased after cue exposed, were allocated to experiment group ( n = 36 ) and control group ( n = 24 ) . The control group dependents received assistance and education. Beside the assistance and education, the experiment group also received 12 times combination therapies of BT and CET. Results: After therapies, the experiment group dependents' craving, EMG and skin conductance ( SC ) were all decreased compared with control group before cue exposures and after cue exposures [ Before cue exposures, the indexes were: craving ( 3.06 ± 7. 26 ) mm vs. ( 22. 32 ± 20.26 ) mm; EMG (8.52 ± 4. 23 ) μV vs. ( 12. 06 ±5. 17) μV, SC (2. 14 ± 1.43 ) μS vs. (4. 61 ± 2. 24)μS. After cue exposures the indexes were: craving (6.97±10.30) mm vs. (33.14±25.40) mm, MEG (8.72±4.31) μN vs. (14.79±5.86) μV, SC (2.15±1.33) μS vs. (4.49±2.59)μS; Ps≤0.01. Conelusion: The combination of biofeedback therapy and cue-exposure therapy could decrease the dependents' craving and cue reactivity sensitivity.

关 键 词:海洛因依赖 线索暴露治疗 生物反馈 渴求 心理生理学 前瞻性队列研究 

分 类 号:R749.6[医药卫生—神经病学与精神病学] R749.059[医药卫生—临床医学]

 

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