联合大剂量弥可保治疗糖尿病脑梗死的临床观察  

Clinical Observation of Large Dose Mecobalamin Injection Associated in Treating Diabetic Cerebral Infarct

作　　者：陈勇军[1] 邹伟[1] 汤永红[2] 张新华[1] 刘淑云[1] 

机构地区：[1]南华大学附属南华医院神经内科,湖南衡阳421002 [2]南华大学第二附属医院神经内科

出　　处：《南华大学学报（医学版）》2009年第6期721-723,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的观察联合大剂量弥可保治疗糖尿病脑梗死的临床疗效。方法糖尿病脑梗死患者共69例,随机分为弥可保组35例和对照组34例,两组均常规使用抗血小板、改善微循环、神经营养等药物,弥可保组加用弥可保2 000μg/d静滴。两组患者治疗前、治疗后3周分别进行欧洲卒中量表评分(ESS)和日常生活活动能力Barthel指数(B I)评估,并且抽血测定血清同型半胱氨酸值(HCY)。结果治疗后弥可保组ESS、B I较对照组有显著增加,而HCY有显著下降。结论联合大剂量弥可保治疗可明显改善糖尿病脑梗死的疗效,其机制可能与减少HCY有关。Objective To observe the effect of large dose mecobalamin injection associated in treating diabetic cerebral infarct. Methods Sixty - nine patients with diabetic cerebral infarct were randomly divided into two groups, both treated by antiplatelet, improving microcirculation and neurotrophy. Mecobalamin group has 35 cases, treated by mecobalamin injection associated,2 000 μg per day, control group has 34 cases. The European stroke scale（ESS） and the Barthel index of activities of daily living（BI） of two groups were rated before treated and 3 weeks later,the content of homecysteine （ HCY） was measured at the same time. All results were compared between two groups. Results ESS and BI in mecohalamin group were significantly higher than control group （ P 〈 0.05 ）, and HCY in cecobalamin group was significantly lower than control group （ P 〈 0.05 ）. Conclusions Large dose mecobalamin injection associated in treating diabetic cerebral infarct has showed obviously therapeutic effect. The mechanism may be related to reducing the content of homocysteine.

关 键 词：弥可保 糖尿病 脑梗死 同型半胱氨酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]