拉莫三嗪对脑卒中后中枢性疼痛的疗效研究  

Study on treatment of central post-stroke pain using lamotrigine

作　　者：张敬军[1] 陈青[2] 左磊[1] 逄孝敬[1] 杜娟[1] 

机构地区：[1]泰山医学院附属医院,山东泰安271000 [2]泰安卫生学校,山东泰安271000

出　　处：《泰山医学院学报》2009年第9期649-651,共3页Journal of Taishan Medical College

基　　金：山东省卫生系统中青年重点科技人才1020工程课题资助项目

摘　　要：目的探讨拉莫三嗪对脑卒中后中枢性疼痛的疗效。方法以盐酸氟西汀为对照,治疗过程中疼痛程度用视觉模拟评分法评价拉莫三嗪对脑卒中后中枢性疼痛的疗效。结果拉莫三嗪与盐酸氟西汀治疗后VAS评分较治疗前明显降低(P<0.01),拉莫三嗪与盐酸氟西汀治疗后VAS评分无显著性差异(P>0.05)。结论拉莫三嗪可有效治疗脑卒中后中枢性疼痛,疗效与盐酸氟西汀相同,未见明显的毒副作用。Objective： To investigate the therapeutic effects of lamotrigine on central post-stroke pain.Methods： The patients with central post-stroke pain were randomly divided into the lamotrigine group and the fluoxetine group.Pain intensity was assessed with visual analogue scale（VAS）.Results： The VAS values were decreased after the treatments in both groups.There was not statistical significant difference in the therapeutic effects after the treatments between the two groups,two groups had less side-effect.Conclusion： Lamotrigine has a good therapeutic effect on central post-stroke pain,which is similar to fluoxetine.

关 键 词：拉莫三嗪 中枢性疼痛 脑卒中 氟西汀 

分 类 号：R743.3[医药卫生—神经病学与精神病学]