利托君的合成  

Synthesis of Ritodrine

作　　者：王立平[1] 李鸿波[1] 梁伍[1] 陈凯[1] 刘浪[1] 

机构地区：[1]西南科技大学材料科学与工程学院,四川绵阳621010

出　　处：《中国医药工业杂志》2009年第12期885-887,共3页Chinese Journal of Pharmaceuticals

摘　　要：苯酚和丙酰氯经酯化及Fries重排得到对羟基苯丙酮,经溴化铜溴代所得α-溴对羟基苯丙酮,在THF中与对羟基苯乙胺进行缩合、硼氢化钾还原,制得抗早产药利托君,总收率约39%。p-Hydroxypropiophenone, which was synthesized from phenol and propionyl chloride by esterification and Fries rearrangement reaction, reacted with CuBr2 to obtain α-bromo-p-hydroxypropiophenone, followed by the condensation with p-hydroxyphenethylamine in THF and reduction with KBH4 to give ritodrine. The overall yield was about 39 %.

关 键 词：利托君 抗早产药 合成 

分 类 号：R979.9[医药卫生—药品]