胃癌特异染色剂对早期胃癌的诊断价值  

Diagnostic values on early gastric cancer by a novel carcinophilia gastric mucosa staining dye

作　　者：孙国庆[1] 孙昊[2] 季晨博[3] 

机构地区：[1]江苏职工医科大学医学护理系,江苏南京210029 [2]江苏省人民医院急救中心 [3]南京市妇幼保健院

出　　处：《中国肿瘤外科杂志》2009年第6期342-344,共3页Chinese Journal of Surgical Oncology

基　　金：江苏省卫生厅立项课题(J200301)

摘　　要：目的探讨一种胃癌特异染色剂对早期胃癌的诊断价值。方法用经20例预试验筛选而最终确定的自配核染色剂进行活体模拟染色试验。标本采自经胃镜及病理确诊的195例胃癌患者。结果胃癌组织均在15％～20％浓度染色剂中短时间（≤30s）内着色，而癌周胃黏膜组织60s及以后才开始着色，两者比较差异有统计学意义（P〈0．05）。不同病理类型的胃癌在不同浓度染色剂下显色时间有所不同。结论自配核染色剂在特定浓度、短时间内可使胃癌组织特异染色，使肉眼可区别癌周黏膜组织，有望成为一种新型的胃癌特异染色剂，用于色素内镜诊断早期胃癌。Objective To evaluate the diagnostic values on early gastric cancer by carcinophilia gastric mucosa staining dye. Methods We chose a nuclear staining dye for experiments after preliminary test with 20 samples and all samples of gastric mucosa tissues of early gastric cancer and advanced gastric cancer were obtained from 195 patients who were diagnosed by endoscope and pathology. Results Four different types of cancer were significantly colored with a low dilution （15% -20% ） in no more than 30 s, while normal gastric mucosa surrounding tissues began to be colored in 60 s at least. There was a significant difference between the two groups, P 〈 0.05. Conclusions Our results suggested that the new nuclear staining dye can specific stain cancer tissues, in a particular concentration within a short time, which was visible, distinct from the surrounding normal mucosa. It has a value of diagnosis of early gastric cancer by chromoendoscopy.

关 键 词：特异染色剂 色素内镜 早期胃癌 

分 类 号：R735.2[医药卫生—肿瘤] R446[医药卫生—临床医学]