肿瘤相关微小RNA与凋亡  

Tumor-associated miRNA and apoptosis

作　　者：南阳(综述)[1] 康春生(审校)[1] 钟跃(审校)[1] 

机构地区：[1]天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤实验室,300052

出　　处：《国际肿瘤学杂志》2009年第11期803-806,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30772231）;教育部新世纪优秀人才支持计划资助（NCET.07.0615）

摘　　要：微小RNA（miRNA）在转录后水平调控基因的表达。研究证实miRNA通过调控细胞的凋亡，在肿瘤的发生发展过程中发挥着重要的作用。肿瘤相关miRNA与凋亡的研究在未来的肿瘤诊疗中miRNA可能具有广阔的应用前景。MicroRNA, known as micro-RNA or miRNA, is a class of small non-coding RNA whose mature products is - 22 nucleotides long. It negatively regulates gene expression at the post-transcriptional level. More and more studies confirm the important role of miRNA in carcinogenesis and tumor development by regulating cell apoptosis,and the research focuses on tumor-associated miRNA in tumor cell apoptosis may bring widest perspective on treatment and diagnosis of tumor in the future.

关 键 词：微小RNAS 凋亡 肿瘤 患者 

分 类 号：R730.53[医药卫生—肿瘤]