1-氨基-1-环烷基甲酸的合成  

Synthesis of 1-Amino-1-cycloalkylformic Acid

作　　者：罗峰[1] 刘帅[1] 姚颖[1] 李子成[1] 李欢[1] 

机构地区：[1]四川大学化工学院,四川成都610065

出　　处：《四川化工》2009年第6期1-3,共3页Sichuan Chemical Industry

摘　　要：通过改进的Strecker法,分别以环己酮和环戊酮为原料与氨反应生成亚胺(Ⅰ),(Ⅰ)与氰化钠反应生成(Ⅱ),(Ⅱ)用浓盐酸水解为α-氨基酸(Ⅲ)。反应最佳条件为:环烷基酮、氨水、氯化铵和氰化钠的摩尔比为:1∶1.8∶1.1∶1.1。粗品α-氨基酸用75%的乙醇重结晶。1-氨基-1-环己基甲酸和1-氨基-1-环戊基甲酸的收率分别为56.42%和60.21%。目标化合物用核磁和红外光谱进行了表征。1-Amino-l-cycloalkylcarboxylic acids were synthesized by improved Strecker reaction from cycloalkyl ketones in 3 steps. The cycloalkyl ketones reacted with ammonia to form imines（ I ） ; I reacted with sodium cyanide to afford the α-amino nitriles （ II ） ; II was hydrolyzed by concentrated hydrochloric acid to give the target α-amino acids（ III ）. The optimal conditions were： molar ratio of cycloalkyl ketone, ammonia, ammonium chloride, and sodium cyanide was 1：1.8：1. 1：1.1; The crude α-amino acids were recrystallized from 75% ethanol. The total yields of 1-amino-l-cyclohexylcarboxylic acid and 1-amino-l-cy- clopentylcarboxylic acid were 56.42%and 60. 21%,respectively. The target compounds were characterized by 1HNMR and IR spectrum.

关 键 词：1-氨基-1-环己基甲酸 1-氨基-1-环戊基甲酸 Α-氨基酸 合成 

分 类 号：TQ235[化学工程—有机化工]