多发性硬化的发作性症状分析  

Analysis of paroxysmal symptoms with multiple sclerosis

作　　者：徐辉[1] 

机构地区：[1]河南商丘市第一人民医院神经内科,商丘476100

出　　处：《中国实用神经疾病杂志》2009年第23期21-23,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨多发性硬化中发作性症状的临床特点、发病机制和治疗方法。方法对15例具有发作性症状的MS患者根据不同临床特点分类,分析影像学、电生理特点,总结其异同点。结果多发性硬化中发作性症状的发生率、临床表现不一,其中以痛性强直发作、发作性感觉异常、Lhermitte征和癫最为常见。结论MS发作症状共同点为突发突止,刻板重复,时间短暂,可能的发病机制是由于中枢神经系统脱髓鞘损害,使神经纤维间的冲动发生横向扩散所致,卡马西平等抗癫药治疗有效。Objective To explore the clinical features, pathogenesis and treatment of paroxysmal symptoms in multiple sclerosis（MS）. Methods We analyzed and studied the clinical manifestations,imaging findings and electrophysiology of 15 patients with paroxysmal symptoms in multiple sclerosis. Results Some 28.3% patients may be seen the paroxysmal symptoms in MS,including paroxysmal paresthesia,Lhermitte sign, painful tonic seizures,epilepsy ect. Conclusion The attacks were flup, stereotyped and short-time. The pathogenic mechanism of the paroxysmal symptoms in MS probably is related to a transversely spreading impulses hy activation of the neuralaxons within the demylinating lesion in the CNS. The symptoms can be controlled with carbamazepine or other antiepileptics.

关 键 词：多发性硬化 发作性症状 

分 类 号：R744.51[医药卫生—神经病学与精神病学]