基质金属蛋白酶-2、-9在宫颈癌进展中的意义  

The significance of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9 (MMP-9) in the course of development of cervical carcinoma

作　　者：徐平[1] 蔡海宁[2] 王丹霞[1] 詹松[2] 

机构地区：[1]北海市人民医院妇科,广西北海536000 [2]北海市人民医院病理科

出　　处：《西部医学》2009年第12期2040-2042,共3页Medical Journal of West China

基　　金：北海市科学研究与技术开发计划课题(No.200701065)

摘　　要：目的探讨从宫颈癌前病变进展至宫颈癌,基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)的表达变化。方法采用免疫组化二步法检测20例慢性宫颈炎、45例宫颈上皮内瘤样变(CIN)、42例宫颈癌中MMP-2、MMP-9蛋白的表达。结果MMP-2、MMP-9在慢性宫颈炎中的表达极低,在各级CIN、宫颈浸润癌阳性表达高,其阳性表达强度随CIN级别增高而增强,至宫颈癌表达强度最高,并有统计学差异;在宫颈癌组织中,MMP-2的表达强度显著高于MMP-9,但宫颈癌的临床分期与MMP-9的表达强度有显著性关系,而与MMP-2的表达强度无显著性关系。结论MMP-2、MMP-9在宫颈癌前病变进展至宫颈癌这一过程中起着重要作用,而MMP-9与宫颈癌进展的关系更为密切,成为判断宫颈癌预后的指标之一。Objective This study was undertaken to explore the significance of matrix metalloproteinase-2 （MMP- 2） and matrix metalloproteinase-9 （MMP-9） in the course of development of cervical carcinoma. Methods We evaluate samples of cervical tissue with immunohistochemistry for MMP-2 and MMP-9 in 5 distinct groups. The groups were divided into chronic cervicitis, CIN I, CIN II, CIN III and cervical invasive carcinoma. Result MMP-2 and MMP-9 expression gradually increased according to the degree of CIN and cervical carcinoma. The expression of MMP-2 was significantly higher than that of MMP-9, but the expression degree of MMP-9 was correlated with the clinical stage of carcinoma. Conclusion MMP-2 and MMP-9 play important roles in the process of CIN developing to carcinoma, but MMP-9 is more important according to the development of carcinoma, which might be a useful prognostic indicator for cervical cancer.

关 键 词：基质金属蛋白酶 宫颈上皮内瘤样变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]