B7-H1蛋白在人胰腺癌组织中的表达及临床意义  

Expression of B7-H1 protein in human pancreatic carcinoma tissues and its clinical significance

作　　者：陈小玲[1,2] 袁苏徐[1] 陈琛[3] 毛一香[4] 徐刚[3] 王宪远[3] 

机构地区：[1]苏州大学附属第一医院肿瘤科,江苏苏州215006 [2]上海市北站医院肿瘤科,上海200070 [3]郑州大学第二附属医院病理科,河南郑州450014 [4]复旦大学附属肿瘤医院肝胆胰肿瘤科,上海200032

出　　处：《癌症》2009年第12期1328-1332,共5页Chinese Journal of Cancer

基　　金：苏州大学青年教师自然科学基金;苏州大学附属第一医院面上科研项目(YT0714)~~

摘　　要：背景与目的:恶性肿瘤细胞表达共刺激分子B7-H1来抑制T细胞功能,逃避机体的抗肿瘤免疫反应。本研究通过检测人胰腺癌组织中B7-H1蛋白的表达,探讨其与胰腺癌患者临床病理指标及预后之间的关系。方法:采用免疫组化法检测B7-H1在40例胰腺癌组织和10例癌旁正常胰腺组织中的表达情况,用卡方检验或确切概率法分析B7-H1的表达与胰腺癌患者各临床病理指标以及生存时间的关系。结果:40例胰腺癌组织中B7-H1阳性率为45.00%(18/40),高于癌旁正常胰腺组织(P<0.05);B7-H1表达与患者肿瘤分期、术前CA19-9有关(P<0.05)。多因素Cox回归模型显示,B7-H1表达是胰腺癌患者无复发生存期、总生存期的独立危险因素。结论:人胰腺癌组织中存在B7-H1蛋白表达,B7-H1表达与胰腺癌患者的预后有关。Background and Objective. B7-H1, a member of B7 family, is expressed in tumor cells and has emerged as an important immune modulator capable of suppressing host immunity by inhibiting T cells function. This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis. Methods： The expression of B7-H1 was measured in 40 cases of pancreatic carcinoma tissues and 10 cases of normal corresponding paracarcinoma tissues by immunohistochemistry. The relationship between the expression level of B7-H1 and clinicopathological characteristics and survival was analyzed. Results; The positive rate of B7-H1 was significantly higher in the tumor tissues [45.00% （18/40）] than in the normal corresponding paracarcinoma tissues [0（0/10） ] （P〈0.05） ; moreover, B7-H1 expression was significantly associated with the staging of tumor and preoperative serum CA19-9 level （P〈0.05）. The multivariate cox proportional hazards regression analysis of prognostic factors for overall survival and relapse-free survival showed that the expression of B7-H1 was an independent factor for poor prognosis. Conclusion： B7-H1 protein was expressed in human pancreatic carcinoma tissues, and was associated with the prognosis.

关 键 词：胰腺癌 免疫组化 B7-H1 预后 

分 类 号：R735.9[医药卫生—肿瘤]