无创尾吊大鼠心血管功能监测新方法  

New method for monitoring the cardiovascular function in invasive tail suspension rats

作　　者：刘广兴[1] 崔猛[1] 刘振国[2] 牛银波[1] 王婷梅[1] 梅其炳[1,2] 

机构地区：[1]西北工业大学生命科学院空间生物实验模拟技术国防重点学科实验室,陕西西安710072 [2]第四军医大学药学系药理学教研室,陕西西安710033

出　　处：《第四军医大学学报》2009年第22期2503-2506,共4页Journal of the Fourth Military Medical University

摘　　要：目的:运用植入式遥测系统建立一种在体的实时监测无创尾部悬吊大鼠心血管生理参数模型.方法:将SD雄性大鼠随机分为对照组,尾吊组,每组5只.手术植入遥测子后记录尾吊前后各组大鼠血压(BP)、心率(HR)、心电图(ECG)变化.结果:所有大鼠在手术14d后完全恢复,体质量显著增加;尾吊组大鼠在尾吊0～5min时BP,HR值逐渐上升,随后逐渐下降,5.5h后维持稳定.其中BP值高于尾吊前及对照组,HR未出现类似状况.RR间期在尾吊0～5min下降,之后逐渐升高至尾吊前水平,对照组大鼠各项参数值无显著变化.结论:植入式遥测系统适用于监测尾吊大鼠心血管生理参数变化,为进一步研究失重引起的心血管功能变化提供了可靠的技术方法和实验依据.AIM：To establish an invasive tail suspension（TS）rats model,which offers real time monitoring of rats＇ cardiovascular parameters.METHODS：Ten Sprague Dawley rats were equally divided into 2 groups at random,the normal group and TS group.Having been followed implantation of radiotelemeter,before and after TS,all rats were monitored the blood pressure（BP）,heart rate（HR）,and ECG waveform et al.RESULTS：All rats＇ bodyweight were increasedsignificantly the fourteenth day after surgery.The BP and HR values of TS rats increased during the first 5 min after TS,and fell down from 5 min to 5.5 h after TS.After 5.5 h,there were no significant changes.However,the BP values were higher than that before TS and that in normal group,while the HR values had no such changes.The RR interval values decreased duringthe first 5 min after TS,and increased to the same level that before TS and after 5 min TS.There were no significant changes during the following days.Besides,there were no significant changes on any of the physiological parameters in normal group rats.CONCLUSION：The implantable radiotelemetry system was suitable for monitoring the changes of cardiovascular parameters in TS rats.It was a reliable method for studying the changes of cardiovascular function coursed by weightlessness.These results have alsoprovided important experimental foundation for further studies.

关 键 词：植入式遥测 心血管参数 尾吊 模型 

分 类 号：R363[医药卫生—病理学]