小牛血去蛋白提取物治疗缺血性脑梗死疗效分析  

Analysis of deproteinized extract of calf blood(DECB) in treatment of ischemic cerebral infarction

作　　者：乐春[1] 徐海松[2] 

机构地区：[1]杭州师范大学附属医院药剂科 [2]杭州师范大学附属医院神经外科

出　　处：《中国临床药理学与治疗学》2009年第8期937-940,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨小牛血去蛋白提取物在缺血性脑梗死患者中的应用价值。方法:将66例缺血性脑梗死患者随机分为对照组和小牛血去蛋白提取物治疗组,治疗组33例予以小牛血去蛋白提取物30mL静脉滴注,1次/日,连续3周。对照组33例除未给予小牛血去蛋白提取物外其它治疗相同。对两组患者治疗前后血液流变学及神经功能缺损程度评分的变化情况进行比较分析。结果:小牛血去蛋白提取物治疗组显效率为72.7%,明显高于对照组(45.5%,P<0.05)。治疗后小牛血去蛋白提取物治疗组全血黏度(低切)、红细胞压积和血小板聚集率均明显低于对照组(P<0.05),且均明显低于治疗前(P<0.05);而血浆黏度两组变化相近。治疗后小牛血去蛋白提取物治疗组的神经功能缺损程度评分明显低于对照组(P<0.05)。结论:小牛血去蛋白提取物对缺血性脑梗死患者有确切疗效,未发现不良反应,可在临床推广。AIM：To explore the application value of deproteinized extract of calf blood （DECB） in patients with ischemic cerebral infarction. METHODS：66 cases of patients with ischemic cerebral infarction were randomly divided into control group and DECB treatment group. DECB treatment group was given 30 mL DECB intravenous drip,once a day,for three weeks. Control group was not given DECB treatment in addtion with other treatment. The hemorheology and neurological deficits and changes in the two groups of patients were analyzed before and after treatment. RESULTS：The obvious effective rate of DECB treatment group was 72.7%,which was significantly higher than that in control group （45.5%,P〈0.05）. After treatment,the whole blood viscosity （low shear）,hematocrit and platelet aggregation in DECB treatment group were significantly lower than those in control group （P〈0.05）. which were also significantly lower than pre-treatment （P〈0.05）. The plasma viscosity had no statistical difference between the groups. The score of neurological deficit of DECB treatment group was significantly lower than that in control group （P〈0.05）. CONCLUSION：The DECB has the exact efficacy on patients of ischemic cerebral infarction. No adverse reactions were found in clinic. It can be used in clinical practice.

关 键 词：小牛血去蛋白提取物 脑梗死 疗效 分析 

分 类 号：R743[医药卫生—神经病学与精神病学]