鼻咽癌患者放疗过程中血清VEGF水平的动态变化  

Dynamic of serum levels of VEGF in nasopharyngeal patients in course of radiotherapy

作　　者：陈秋燕[1] 张昌卿[2] 莫浩元[1] 邓满泉[1] 曹素梅[1] 洪明晃[1] 郭翔[1] 麦海强[1] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学肿瘤防治中心鼻咽癌科,广东广州510060 [2]华南肿瘤学国家重点实验室中山大学肿瘤防治中心实验研究部,广东广州510060

出　　处：《中华肿瘤防治杂志》2009年第18期1424-1426,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(No.30600755);"863"计划(No.2006AA02A404);广东省科委项目(No.2007B0604010-64);广东省医学科研基金(No.B2006063);华南肿瘤学国家重点实验室基金(No.985-2)

摘　　要：为了观察鼻咽癌放疗过程中血清VEGF水平的动态变化,为放射治疗联合靶向VEGF治疗鼻咽癌提供理论依据,对33例鼻咽癌初治患者在治疗前、治疗期间及治疗后每周抽血检测血清中VEGF一次,采用ELISA酶连免疫吸附实验检测血清VEGF浓度。鼻咽癌患者放疗前、放疗中和放疗后的血清VEGF值分别为(308.63±203.04)、(483.36±245.11)和(381.41±249.95)ng/L。放疗前VEGF浓度与放疗中、放疗后浓度差异有统计学意义,P值分别为0.003、0.008,而放疗中与放疗后差异无统计学意义,P=0.209;放疗期间血清VEGF最高值以放疗第3～5周为主,占血清VEGF最高值周数的63.7%。初步研究结果提示,鼻咽癌患者放疗期间血清VEGF水平较治疗前明显升高,放射治疗联合靶向VEGF治疗鼻咽癌疗效显著,值得应用。This study was intend to observe the dynamic of serum levels of VEGF （sVEGF） in nasopharyngeal patients in the course of radiotherapy,and provide an evidence to cure NPC through radiotherapy associated with targeting VEGF. sVEGF in 33 nasopharyngeal carcinoma （NPC） patients were detected by ELISA every week before the treatment,in the course of the treatment and after the treatment. The sVEGF before radiotherapy,among radiotherapy and after radiotherapy were （308.63±203.04） ng/L,（483.36±245.11） ng/L,and （381.41±249.95） ng/L respectively. SVEGF before radiotherapy was higher than sVEGF among radiotherapy and after radiotherapy （P=0.003,P=0.008）,but there was no difference between sVEGF among radiotherapy and after radiotherapy （P=0.209）. In the course of radiotherapy,the time of highest sVEGF was most in 3-5 weeks,and the proportion was 63.7%. The preliminary results showed that sVEGF in the course of radiotherapy was obvious higher than sVEGF before radiotherapy in the NPC patients. Radiotherapy associated with targeting VEGF may be effect in the treatment of NPC.

关 键 词：鼻咽肿瘤/放射治疗 血管内皮生长因子 鼻咽肿瘤/A液 

分 类 号：R739.63[医药卫生—肿瘤]