胃黏膜胆色素染色对原发性病理性十二指肠胃反流的诊断价值  

Study of porphobilin staining of gastric mucosa on diagnosis of primary pathological duodenogastric reflux

作　　者：韩俊岭[1] 姜东春[1] 韩莹[2] 杨艳红[1] 任凤杰[1] 曲磊红[1] 郑岳[1] 姚树坤[3] 

机构地区：[1]秦皇岛市第一医院消化内科,河北秦皇岛066000 [2]秦皇岛港口医院检验科 [3]卫生部中日友好医院

出　　处：《中国老年学杂志》2009年第22期2848-2850,共3页Chinese Journal of Gerontology

基　　金：河北省科学技术研究与发展指导计划项目(072761861)

摘　　要：目的探讨胃黏膜胆色素染色对原发性病理性十二指肠胃反流的诊断价值。方法86例原发性病理性十二指肠胃反流病人和42例正常志愿者对照胃黏膜胆色素染色后进行定量分析,应用便携式胆汁监测仪(Bilitec2000)监测胃内24h胆汁反流情况,以胆红素吸收值≥0.25的时间百分比作为评价胆汁反流程度的主要观察指标。结果病例组中胃窦、胃角和胃体部黏膜胆色素沉积显著高于正常对照组(P<0.01),胃窦和胃角部黏膜胆色素沉积显著高于胃体部(P<0.01);病例组中胃窦和胃角部黏膜胆色素沉积与胃窦和胃角部黏膜新悉尼系统病理积分均呈正相关(r=0.521,P=0.000和r=0.468,P=0.002),胃体部黏膜胆色素沉积与胃体部黏膜新悉尼系统病理积分无相关性(r=0.185,P=0.236);病例组中胃窦和胃角部黏膜胆色素沉积与胆红素吸收值≥0.25的时间百分比均呈正相关(r=0.458,P=0.002和r=0.334,P=0.028),胃体部黏膜胆色素沉积与胆红素吸收值≥0.25的时间百分比无相关性(r=0.092,P=0.556)。结论胃窦部黏膜胆色素染色能够反映胆汁反流程度,并与黏膜损伤程度呈正相关,对原发性病理性十二指肠胃反流有诊断价值,可用于原发性病理性十二指肠胃反流的辅助诊断。Objective To study the value of porphobilin staining of gastric mucosa on diagnosis of primary pathological duodenogastric reflux.Methods Porphobilin staining of gastric mucosa of 86 cases in primary pathological duodenogastric reflux group and 42 cases in normal group were measured by quantitative diagnosis.24 hour intragastric bilirubin monitoring was measured by using Bilitec 2000 and time percentage of bilirubin absorbance ≥0.25 was used as threshold to evaluate the severity of bile reflux.Results The deposition of porphobilin in mucosa of gastric antrum,gastric anguli and gastric body in primary pathological duodenogastric reflux group were significantly severer than those of normal group（P0.01）.The deposition of porphobilin in mucosa of gastric antrum and gastric anguli were significantly severer than those of gastric body in primary pathological duodenogastric reflux group（P0.01）.The deposition of porphobilin in mucosa of gastric antrum and gastric anguli were positively correlated with New Sydney system pathological scores of gastric antrum and gastric anguli in primary pathological duodenogastric reflux group（r=0.521,P=0.000 and r=0.468,P=0.002）.The deposition of porphobilin in mucosa of gastric body was not correlated with New Sydney system pathological scores of gastric body in primary pathological duodenogastric reflux group（r=0.185,P=0.236）.The deposition of porphobilin in mucosa of gastric antrum and gastric anguli were positively correlated with time percentage of bilirubin absorbance ≥0.25 in primary pathological duodenogastric reflux group（r=0.458,P=0.002 and r=0.334,P=0.028）.The deposition of porphobilin in mucosa of gastric body was not correlated with time percentage of bilirubin absorbance ≥0.25 in primary pathological duodenogastric reflux（r=0.092,P=0.556）.Conclusions Porphobilin staining of mucosa in gastric antrum can reflect the severity of bile reflux,and it is positively correlated with the extent of gastric mucosal lesion.Porphobilin staining of gastric mu

关 键 词：原发性病理性十二指肠胃反流 胆汁监测 胆色素染色 

分 类 号：R573.9[医药卫生—消化系统]