重组人血管内皮抑素联合伽玛刀治疗多种晚期恶性肿瘤的临床观察  

Clinical observation of recombinant human endostatin combined stereotactic radiotherapy in advanced malignant tumors

作　　者：董桂云[1] 叶斌[2] 虞喜豪[1] 李新娉[1] 熊莺[1] 肖作平[1] 

机构地区：[1]解放军第八五医院伽玛刀病房,上海200052 [2]上海应用技术学院化学工程系,200235

出　　处：《临床肿瘤学杂志》2009年第11期1035-1037,共3页Chinese Clinical Oncology

摘　　要：目的:观察重组人血管内皮抑素(恩度)联合体部伽玛刀治疗多种晚期恶性肿瘤的有效性和安全性。方法:经影像学或病理学确诊的晚期恶性肿瘤患者21例,其中包括肺癌8例,结肠癌6例,原发性肝癌2例,胰腺癌2例,卵巢癌1例,胃癌1例,食管癌1例。接受恩度治疗同时联合体部伽玛刀治疗,其中恩度15mg,加入生理盐水500ml中匀速缓慢静脉滴注,维持3～4小时,第1～14天连续给药,间歇7天;静滴恩度同时联合体部伽玛刀治疗。21天为1个周期。2周期后评价疗效。按照RECIST标准评价近期疗效,参照Karnofsky评分(KPS)变化评价生活质量。结果:全组21例患者,20例完成伽玛刀治疗,1例因既往有房颤病史,合并心功能衰竭退出。20例可以评价客观疗效,平均每例完成2.1个周期,获得PR 14例,SD 4例,PD 2例。12例生活质量(QOL)改善,5例稳定,3例下降。毒副反应轻微,经对症处理均可以缓解。结论:恩度与体部伽玛刀联合治疗晚期恶性肿瘤患者疗效较好,生活质量明显改善,两者具有协同作用,安全性亦较好。Objective：To evaluate the clinical implication of recombinant human endostatin（endostar） in combination with stereotatic radiation therapy（SRT） in advanced tumors.Methods：We performed 21 patients with advanced malignant tumors,treated with endostar injection combined with body gamma knife.Add endostatin into 500ml NS just befor the use drip intravenously at uniform speed for 3-4h.Continously at 7.5mg/m2,once a day during days 1-14 of treatment cycle only after the rest for 1 week（generally 2-4 cycles）.At the time having the trentment of stereotactic radiothearpy.Results：Twenty patients had completed the treatment.The remission rate of the effectiveness was 90%（18/20）.Twelve cases acquired improvement of QOL,5 cases were stable,3 cases were decline.The side effects were mild and tolerable.Conclusion：Endostar combined body gamma knife is safe and effective in the treatment of advanced malignant tumors,which should be further explored in clinic.

关 键 词：重组人血管内皮抑素/恩度 恶性肿瘤 体部伽玛刀 

分 类 号：R730.53[医药卫生—肿瘤]