Determination of brain iron content in patients with Parkinson’ s disease using magnetic susceptibility imaging  

磁敏感成像检测帕金森氏病脑铁沉积(英文)

作　　者：张蔚[1,2] 孙圣刚[2] 蒋宇宏[2] 乔娴[1] 孙欣[1] 吴艳[1] 

机构地区：[1]华中科技大学附属协和医院神经内科,武汉430022 [2]华中科技大学附属中西医结合医院放射科,武汉430022

出　　处：《Neuroscience Bulletin》2009年第6期353-360,共8页神经科学通报（英文版）

摘　　要：Objective To compare the phase radians in several cerebral regions between patients with Parkinson’s disease （PD） and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging （SWI） is related to the severity of motor symptoms of PD. Methods SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo （GRE） sequence. Magnitude and phase data were collected at GE HD 1.5T. The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus （CN）, sub- stantia nigra pars compacta （SNc）, substantia nigra pars reticulata （SNr）, and red nucleus （RN）. A total number of 42 patients （12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees） and 30 control subjects were employed in the present study. Results The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects （P〈0.05）. Conclusion The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.目的比较帕金森氏病(Parkinson’s disease,PD)患者和健康对照者多个脑结构的相位偏移值(phase radians),探讨相位偏移值的临床应用价值。方法42名PD患者及30名年龄匹配的健康对照者均在1.5TMR系统中进行头部检查。所有PD患者均存在轻度到中度认知功能缺损。采用磁敏感成像获得相位图,测量双侧尾状核、壳核、黑质致密带、黑质网状带、红核、脑脊液、额叶白质及额叶灰质内所感兴趣区的相位偏移值。结果与正常对照组相比,PD组黑质致密带的相位偏移值均数显著缩短(P<0.05)。此外,PD组双侧尾状核和红核的相位偏移值亦显著降低(P<0.05),而黑质网状带的相位偏移值与对照组相比无统计学差异(P>0.05)。结论通过对相位偏移值的测定可以估测PD患者脑内的铁沉积,为PD的活体诊断及病情监测提供帮助。

关 键 词：Parkinson’s disease phase radians susceptibility-weighted imaging iron deposition 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]