含诺维本的联合化疗对47例中晚期肺癌的近期疗效  

Clinical Analysis of 47 Cases of Advanced Lung Cancer Treated by Navelbine Cisplatin and Adriamycin

作　　者：郝吉庆[1] 熊自姐[1] 

机构地区：[1]安徽医科大学第一附属医院

出　　处：《河南肿瘤学杂志》1998年第4期275-276,共2页Henan Journal of Oncology

摘　　要：目的：探讨含诺维本的联合化疗治疗中晚期肺癌的近期疗效及毒副反应。方法：应用以诺维本为主，与顺铂及阿霉素联合治疗47例中晚期肺癌有效率及毒副反应。结果：47例中晚期肺癌总有效率为48．9％。其中非小细胞肺癌有效率为56．8％（肺鳞癌为57．8％，肺腺癌为55．6％），小细胞肺癌有效率为20％.两组差异显著（P＜0．05），而鳞癌和腺癌疗效无明显差别（P＞0．05）。本方案毒副反应主要是骨髓抑制、神经毒性，胃肠道反应则较少。结果提示含有诺维本的联合化疗不仅对非小细胞肺癌有较好疗效，且毒副反应较轻。结论：含有诺维本的联合化疗，是一个值得临床更深入研究及应用的治疗非小细胞肺癌方案。To study the response rate and the side effect of advanced lung cancer treated by Navelbine, Cisplatin and Adriamycin. Method: The response rate and the side effect were studied in 47 cases ofpatients with advaned lung caner. Results: The total response rate was 48. 9% - Among them, the response the of SCLC was 20% and NSCLC was 56. 8% (squamous - cancer was 57. 8%, adenovarcinoma cancer 55. 6% ). Significant differece was found betwee NSCKC and SCTC (P < 0.05). But the response rate of squamous cancer was similar to that of adenocarcinoma . The main side effect was myelosuppression, and the toxcity of nerve and pestroenteric was mild. The result showed that the therapeutic regimen not onl ygave a higher treatment effect ,but also and the dise effect was mild; Conclusion:The therapeutic regimen was worthy to be further investigated .

关 键 词：中晚期 肺癌 诺维本 顺铂 阿霉素 治疗 

分 类 号：R734.205[医药卫生—肿瘤]