帕罗西汀短程治疗抑郁症的药物不良反应监测  

Monitoring of Adverse Drug Reaction of Paroxtine in the Short-term Treatment of Depression

作　　者：周六枝[1] 王济中[1] 毛明珍 

机构地区：[1]皖南医学院弋矶山医院,241001 [2]安徽东至葛公医院,247200

出　　处：《药物流行病学杂志》1998年第3期146-148,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：帕罗西汀(Paroxtine)短程(6周)治疗抑郁症患者200例,出现药物不良反应(ADRs)162例,310例次,发生率81.00%;轻度35.80%,中度46.91%,重度17.28%;男(81.08%)女(87.66%)无显著差异(P>0.05).各年龄ADRs发生率接近,但40岁以上患者ADR表现程度有随年龄增加而增强趋势.40mg/d治疗ADRs发生率(85.27%)及重度ADRs表现发生率(31.88%)均高于30mg/d组(79.46%,12.00%)和20mg/d组(77.27%,11.76%).多数ADRs在1～2周内出现.Paroxitine was used for the short-term (6 weeks) treatment of 200 patients with depression. 162 cases (320 case times) developed adverse drug reactions (ADRs) with incidence being 81.00%. A-mong them, 35% had slight ADRs, 46.91% had moderate ADRs and 17% had severe ADRs. In our series, the incidence of males was 81.08% and the incidence of females was 87.66% and the difference between two sexes was not significantly significant (P>0.05). The incidences in different age groups were similar but in patients over 40 the ADR incidence tended to increase with age. In 40 mg/day group the total incidence was 85.27% and the incidence of severe ADRs was 31.88%. which were all higher than those in of 30 mg/d group (79.46% and 12.00%) and those of 20 mg/day group (77.27% and 11.76%). Most ADRs occurred within 1-2 weeks after the treatment.

关 键 词：帕罗西汀 短程治疗 抑郁症 药物不良反应 

分 类 号：R749.405[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]