前循环脑梗死患者颈部动脉粥样硬化与MMP-9的关系  

Relationship between carotid arteries plaque in acute anterior circulation territory infarction and matrix metalloproteinase-9.

作　　者：徐耀[1] 李军[1] 俞龙[1] 刘筱洁[1] 杨德刚[1] 

机构地区：[1]扬州大学附属江苏省苏北人民医院神经内科,江苏扬州225001

出　　处：《临床和实验医学杂志》2009年第12期4-5,共2页Journal of Clinical and Experimental Medicine

基　　金：江苏省扬州市科委立项项目;江苏省扬州市社会发展计划项目Wb20052022

摘　　要：目的研究急性前循环脑梗死患者颈部大动脉粥样硬化斑块与血清基质金属蛋白酶9(MMP-9)水平的关系。方法87例急性前循环脑梗死患者入院后立即检查颈部血管超声、血清MMP-9、常规生化检查、血常规。结果前循环急性脑梗死患者颈部血管无斑块者29例,硬斑块26例,软斑块32例,其软斑块组血清MMP-9含量明显增高,所有急性脑梗死者血常规中白细胞计数均高。结论前循环脑梗死患者急性期血清MMP-9含量与颈部大血管软斑块呈正相关,是预测颈部动脉斑块脱落的重要指标之一。各种降低血清MMP-9的治疗在缺血性脑血管病的治疗中有重要意义。Objective To study the relationship between carotid athemmatous plaque in acute anterior circulation territory infarction and matrix metallopmteinase -9 （MMP -9 ）. Methods The level of blood sugar, blood lipid, blood pressure , serum MMP -9, white blood cell and ultrasound of bilateral carotid arteries were examined in 87 patients with acute anterior circulation territory infarction. Results Twenty - nine patients had no carotid plaques, the soft plaques were found in 32 patients, and hard plaques in 26 patients. Serum MMP -9 level was significantly higher in soft plaque group. The white blood cell count was high in all patients. Conehmiou Serum MMP - 9 level shows positive correlation with soft plaque in carotid arteries. The increased level of serum MMP - 9 may be a predictor of disruption of arteriosclerosis plaque in acute anterior circulation territory infarction. All therapies of decreasing serum MMP - 9 may have important roles.

关 键 词：基质金属蛋白酶9 前循环脑梗死 颈部血管斑块 白细胞 

分 类 号：R743.3[医药卫生—神经病学与精神病学]