玉米种子粗多糖的结构及其免疫调节作用研究  

Investigation on the Structure and Immunomodulating Activities of Polysaccharides from the Seeds of Zea Mays

作　　者：邓安珺[1] 李志宏[1] 王霖[2] 彭珊瑛[2] 刘洋[2] 王文杰[2] 秦海林[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050 [2]中国医学科学院北京协和医学院药物研究所药理室,北京100050

出　　处：《国际中医中药杂志》2009年第6期490-492,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的研究玉米粗多糖的主要糖苷键结构及其对小鼠免疫调节功能的影响。方法用热水抽提法和沉淀复溶法提取、分离、纯化玉米粗多糖，根据玉米粗多糖的理化性质及波谱数据鉴定其结构；采用免疫药理学实验评价玉米粗多糖的生物活性。结果分离得到的玉米粗多糖具有与米糠多糖一致的化学结构，为一种以α-1，4和α-1，6糖苷键形式结合的葡聚糖；玉米粗多糖多项免疫药理学指标表明其具有显著的生物活性。结论首次从玉米种子中分离鉴定了玉米粗多糖，其对小鼠免疫功能具有显著的调节作用。Objective To investigate the glycosidic linkage and immunomodulating activities of crude polysaccharides from the seeds of Zea mays. Methods Extraction, isolation and purification ofpolysaccharides were carried out with boiling-water extraction plus resolving deposit repeatedly. The structure was elucidated on basis of physicochemical properties and spectral data, and the biological activities were evaluated by means of Immunopharmacological examination. Results The structure of polysaccharides from the seeds of Z. mays exhibited identical structure with rice bran polysaccharides, i.e., a kind of glucan with α-1,4 and α-1,6 glucosidic bonds as the main frame. Conclusion Polysaccharides was obtained from the seeds ofZ. mays for the first time, and it showed significant immunomodulating activity in mice.

关 键 词：玉米 粗多糖 免疫调节作用 

分 类 号：R285.5[医药卫生—中药学] R284.1[医药卫生—中医学]