腺苷蛋氨酸(思美泰)治疗淤胆型肝炎的疗效观察  

Efficacy observation of succinic acid-adenosylmethionine treatment of cholestatic hepatitis

作　　者：陈达[1] 林恢[1] 

机构地区：[1]福州市传染病医院,350025

出　　处：《临床合理用药杂志》2009年第22期15-16,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察腺苷蛋氨酸(商品名:思美泰)治疗肝内胆汁淤积的临床疗效。方法90例淤胆型肝炎患者随机分为治疗组及对照组各45例,2组均予以保肝治疗,治疗组加用思美泰治疗,对照组加用前列腺素E1治疗。比较思美泰治疗肝内胆汁淤积黄疸血清总胆红素(TBiL)、丙氨酸转氨酶(ALT)、谷氨酸转肽酶(r-GT)、碱性磷酸酶(AKP)的变化。结果治疗组总有效率高于对照组(P<0.05);治疗组治疗后TBiL、ALT、GGT、AKP均明显低于治疗前(P<0.05或P<0.01),且改善情况优于对照组(P<0.05或P<0.01)。结论淤胆型肝炎治疗方案中,思美泰为一种良好的优选药物。Objective To observe the clinical efficacy of succinic aicd-adenosylmethionine on the treatment of cholestatic hepatitis.Methods 90 cases of cholestatic hepatitis were randomly divided into treatment group and control group,45 cases of each group.The two groups were given medication to protect the liver,the treatment group was given succinic aicd-adenosylmethionine,the control group was given prostaglandin E1 treatment.Observed the effect of these two groups,and the changes of serum total bilirubin（TBiL）,, alanine aminotransferase （ ALT）, glutamic acid-GT （GGT） and alkaline phosphatase （ AKP ）.Results The total effective rate in treatment group was higher than that of control group. Compared with those before treat- ment, after treatment the TBiL, ALT, GGT, AKP of treatment group were significantly lower （ P 〈 0.05 or P 〈 0.01 ）, and the situation improved were better than the control group （P 〈 0.05 or P 〈 0.01 ）. Conclusion Succinic aicd-adenosylmethionine was an ideal treatment for cholestatic hepatitis.

关 键 词：淤胆型肝炎 腺苷蛋氨酸 临床疗效 

分 类 号：R575.1[医药卫生—消化系统]