胃癌肝转移术后肝动脉灌注化疗临床观察  

Clinical study of hepatoarterical catheter chemotherapy for gastric carcinoma with liver metastasis

作　　者：吕强声[1] 王亚东[2] 程辉[1] 陆峰[1] 高远东[1] 

机构地区：[1]江苏省滨海县人民医院普外科,224500 [2]阜宁县人民医院普外科

出　　处：《肿瘤研究与临床》2009年第12期813-814,817,共3页Cancer Research and Clinic

摘　　要：目的观察肝动脉灌注化疗对胃癌肝转移的临床疗效。方法回顾性分析2003年1月至2009年1月收治的胃癌肝转移患者31例的临床资料，全部患者均施行相对胃癌根治术，治疗组17例，术中置肝动脉化疗泵，术后行肝动脉灌注化疗；对照组14例，术后行全身静脉化疗。结果随访时间为4～57个月，治疗组近期有效率为88．3％（15／17），1、2、3年生存率分别为88．2％、62．7％、28．9％，未出现需要特殊治疗的不良反应；而对照组近期有效率为28．6％（4／14），1、2、3年生存率分别为68．1％、38．9％、13．0％，化疗不良反应重，两组比较差异有统计学意义（χ^2=12．87、P〈0．05，χ^2=5．511，P〈0．01）。结论肝动脉灌注化疗治疗胃癌肝转移的方法有效，不良反应轻，优于全身静脉化疗。Objective To study the effect and value of hepatoarterical catheter chemotherapy in treating gastric carcinoma with liver metastasis. Methods A total of 31 cases of gastric carcinoma with liver metastasis undergoing radical operation were preoperatively randomly divided into 2 groups： Regional infusion chemotherapy （treatment group, 17 cases） and peripheral venous chemotherapy （control group, 14 cases）. Results The short-term effectiveness of the treatment group was 88.3 %（15/17）. The survival rates of 1, 2, 3 year were 88.2 %, 62.7 %, 28.9 %, respectively. However, the short-term effectiveness of the control group was 28.6 %（4/14）. The survival rates of 1, 2, 3 year were 68.1%, 38.9 %, 13.0 %, respectively. There was obvious difference between the two groups （χ^2= 12.87, P 〈0.05;χ^2 =5.511, P〈0.01）. Conclusion Hepatoarterical catheter chemotherapy is effective for gastric carcinoma with liver metastasis undergoing radical operation and has less toxic side effects.

关 键 词：胃肿瘤 肿瘤转移 化学疗法 肿瘤 局部灌注 

分 类 号：R735[医药卫生—肿瘤]