P16^(INK4)蛋白在30例肝细胞癌组织中的表达  

P16^(INK4)Protein expression in hepatocellular carcinoma (HCC) of 30 patients

作　　者：张胜亮[1] 张耀铮[1] 

机构地区：[1]大连医科大学检验系临床生化教研室

出　　处：《大连医科大学学报》1998年第3期21-23,共3页Journal of Dalian Medical University

摘　　要：应用免疫组化技术研究Ｐ１６ＩＮＫ４蛋白在肝癌细胞中的表达及在肝癌发生发展中的作用。３０例肝癌组织有１６例Ｐ１６ＩＮＫ４蛋白表达阳性，阳性率为５３３３％，１５例正常肝组织Ｐ１６表达阳性率为１００％（Ｐ＜００１）。乙型肝炎病毒（ＨＢＶ）在Ｐ１６ＩＮＫ４蛋白阳性及阴性的肝癌中的感染率分别为７０％及８３３３％，统计学分析两组没有显著差异（Ｐ＞００５）。To study the expression of P16^(INK4)protein in hepatocellular carcinomas and the relationship between the absence of P16^(INK4)protein and the development of hepatocellular carcinomas(HCC), P16^(INK4)Pprotein in specimens from 30 cases of HCC and 15 normal liver tissues as controls was examined immunohistochemistrical. P16^(INK4)protein was detected in 53.33% of HCC and in 100% of normal liver tissues.There was significant difference in the expression of P16^(INK4)between hepatocellular carcinoma and nomal liver tissues(P<0.01)。The positve rates of HBV infection in HCC with and without P16^(INK4) protein expresion were 70% and 8333% respectively(P<0.05).The absence of P16^(INK4) protein may be asscciated with hepatocarcinogenesis.

关 键 词：癌组织 P16^INK4 基因表达 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]