喹硫平与利培酮治疗老年精神分裂症的对照研究  

Comparative of Quetiapine and Risperidone in the treatment of senile schizophrenia

作　　者：罗瑜[1] 张霞[1] 张菁[1] 

机构地区：[1]无锡市精神卫生中心,江苏无锡214151

出　　处：《中国民康医学》2009年第24期3110-3110,3214,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:比较喹硫平与利培酮治疗老年精神分裂症的临床疗效与安全性。方法:将64例老年精神分裂症患者随机分为两组,分别以喹硫平与利培酮治疗,疗程8周。采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效和不良反应。结果:两组治疗后与治疗前各时点PANSS总分、阳性症状、阴性症状及一般病理症状评分比较,差异有显著性或非常显著性(P<0.05或P<0.01)。而治疗后各时点组间差异无统计学意义(P>0.05)。喹硫平组显效率为65.6%,有效率为84.4%;利培组分别为62.5%、81.3%。两组间显效率及有效率差异无统计学意义(x^2=0.07,0.11,P>0.05)。喹硫平组副反应少于利培酮组,治疗期间两组合用苯海索及苯二氮(?)类药物差异有显著性(P<0.01)。结论:喹硫平与利培酮治疗老年精神分裂症疗效相当,但喹硫平不良反应轻,安全性更高。Objective： To compare the efficacy and safety of Quetiapine and Bisperidone in the treatment of senile schizophrenia. Methods： Sixty - four senile schizophrenic in patients were divided into two groups randomly. They were treated with Quetiapine and Pdsperidone respectively for 8 weeks. The positive and negative syndrome scale（PANSS） and treatment emergent symptoms scale （TESS） were used to evaluate efficacy and side effeets.Results： The total and factor scores of PANSS in both groups decreased singinficantly at any time point after treatment（P 〈 0.05 或 P〈0.01）. But there were no singinfieant difeference between the two groups（ P 〉 0.05）, The responsive rate and effective rate were 65.6% and 84.4 % respectively in Quetiapine group and 62.5% and 81.3% in Risperidone group without singinficant difeference between the two groups. TESS showed Quetiapine had less side effects and better safety than Bisperidone.

关 键 词：喹硫平 利培酮 精神分裂症 老年 

分 类 号：R749.3[医药卫生—神经病学与精神病学]