急性髓系白血病缓解前后克隆性演变探讨  

STUDY ON THE CLONALITY EVOLUTION OF ACUTE MYELOID LEUKEMIA BEFORE AND AFTER REMISSION

作　　者：李克[1] 王立[1] 郝玉书[1] 晁恒军 孟庆祥 冯宝璋 崔文[1] 唐克晶[1] 卞寿庚[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所,天津市南京路288号300020

出　　处：《白血病》1998年第3期132-135,共4页

摘　　要：为了动态观察急性髓系白血病（AML）完全缓解（CR）前后的克隆性演变及其与骨髓细胞染色体核型和临床转归的关系。采用人雄激素受体（HUMARA）基因多态性──甲基化分析的方法对15例杂合子女性AML患者缓解前后的克隆性进行了分析。结果显示：15例AML患者缓解方均为单克隆造血，经化疗完全缓解（CR）后其中的11的恢复为多克隆性造血，余4例仍为单克隆性造血，后者中的一例在检查后3个月复发，未发现CR后的克隆性与骨髓三系病态造血有何关系。AML为一克隆性疾病，大部分AML患者CR后恢复正常多克隆性造血，但的有1／4的患者仍为单克隆造血。To study the clonality evolution of AML and the relationship between clonality and clinic,we analysed the clonal pattern of 15 AML before and after remission using thepolymorphism of X-linked HUMARA gene. The outcome showed that all untreated AMLpatients were monoclonal hematopoeiesis. Eleven(73% ) were polyclonal hematopoiesis in 15AML patients after remission, but the other four patients were monoclonal hematopoiesis.of four patients with monoclonal remission,one relapsed after 3 months of detection of theclonality after remission have no obvious relationship with trilineage myelodysplasia in BM.Conclusion was made that: AML is a clonal disease,and most of AML patients recover polyclonal hematopoiesis during remission,with about one-forth our patients being clonal remission.

关 键 词：HUMARA基因 急性 白血病 缓解 克隆性 

分 类 号：R733.710.2[医药卫生—肿瘤]