NR2B在硝酸甘油诱导的大鼠偏头痛中的表达变化所起作用的研究  

Investigation of expression of NR2B in trigeminal ganglion of the migraine rat model

作　　者：申崇标[1] 曾照芳[1] 

机构地区：[1]重庆医科大学检验系,临床检验诊断学省部共建教育部重点实验室、重庆市重点实验室,重庆400016

出　　处：《激光杂志》2009年第6期78-79,共2页Laser Journal

基　　金：重庆市自然科学基金(CSTC,2007BB5287)

摘　　要：目的:探讨在硝酸甘油(Nitroglycerin,NTG)诱导大鼠偏头痛中NMDA受体NR2B亚基的作用。方法:通过皮下注射硝酸甘油构建偏头痛大鼠模型,采用RT-PCR、免疫组织化学法检测三叉神经节中NR2B的表达变化。结果:偏头痛大鼠三叉神经节NR2B的mRNA和蛋白表达量较对照组明显升高(P<0.05)。结论:NR2B通过神经传导可在偏头痛发病中起到重要作用。Objective： to observe the expression of NMDA receptor NR2B subunit in nitroglycerin-induced experimental rat migraine.Methods： Rat migraine model was established by hypodermic adopted,RT-PCR and Immunohistochemical was used to observe the expression of NR2B in trigeminal ganglion.Results： NR2B of the migraine rat model in its trigeminal ganglion is obviously higher than the control group in the mRNA and protein expression levels（P 0.05）.Conclusion： NR2B might play a cenrtral role in migraine central hypersensitivity mechanisms.

关 键 词：NMDA NR2B:偏头痛 NO 

分 类 号：R477[医药卫生—护理学]